TRATAMIENTO FARMACOLOGICO DEL ATONTAMIENTO MIOCARDICO: PAPEL POTENCIAL DEL LEVOSIMENDAN





TRATAMIENTO FARMACOLOGICO DEL ATONTAMIENTO MIOCARDICO: PAPEL POTENCIAL DEL LEVOSIMENDAN

(especial para SIIC © Derechos reservados)
El atontamiento miocárdico que se desencadena en el contexto de la reperfusión coronaria en los síndromes isquémicos agudos puede dar lugar a una situación de insuficiencia cardíaca, e incluso shock cardiogénico, cuyo tratamiento constituye un desafío clínico. El levosimendán, agente sensibilizante al calcio posee propiedades farmacocinéticas, farmacodinámicas y un perfil de seguridad que podrían ser de gran utilidad el tratamiento de esta situación clínica.
Autor:
Martín Jesús García González
Columnista Experto de SIIC

Institución:
Hospital Universitario de Canarias


Artículos publicados por Martín Jesús García González
Coautor
Martín Jesús García González* 
Médico, Hospital Universitario de Canarias, Tenerife, España*
Aprobación
16 de Marzo, 2007
Primera edición
29 de Mayo, 2008
Segunda edición, ampliada y corregida
7 de Junio, 2021

Artículo completo

(castellano)
Extensión:  +/-4.08 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Cardiología, Cuidados Intensivos
Relacionadas: Bioquímica, Cirugía, Farmacología, Medicina Farmacéutica, Medicina Interna



Comprar este artículo
Extensión: 4.08 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
MJ García González, Coronary Care Unit, Department of Cardiology, Hospital Universitario de Canarias, 38320, Ctra. La Cuesta - Taco s/n, Ofra. S. Cristóbal de La Laguna, Tenerife, España
Bibliografía del artículo
1. Heyndrickx Gr, Millard RW, McRitchie RJ, et al. Regional myocardial functional and electrophysiological alterations after a brief coronary artery occlusion in conscious dogs. J Clin Invest 1975; 56:978-995.
2. Braunwald E, Kloner RA. The stunned myocardium: prolonged postischemic ventricular dysfunction. Circulation 1982; 66:1146-1149.
3. Bolli R, Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 1999; 79:609-634.
4. Mann DL, Young JB. Basic mechanisms in congestive heart failure. Recognizing the role of proinflammatory cytokines. Chest 1994; 105:897-904.
5. Adamopoulos S, Parissis JT, Kremastinos DTh. A glossary of circulating cytokines in chronic heart failure. Eur J Heart Failure 2001; 3:517-526.
6. Meldrum DR, Meng X, Dinarello CA, et al. Human myocardial tissue TNF-alpha expression following acute global ischemia in vivo. J Mol Cell Cardiol 1998; 30:1683-1689.
7. Manito N, Kaplinsky EJ, Pujol R. Tratamiento inotrópico en la insuficiencia cardíaca: aspectos generales y resultados clínicos. Med Clin (Barc) 2004; 122:269-274.
8. Taniyama Y, Ito H, Iwakura K, et al. Effects of intracoronary injection of verapamil and nicorandil on microcirculation and left ventricular function inpatients with reperfused myocardial infarction. (abstr) Circulation 1995; 92:177.
9. Sheiban I, Tonni S, Chizzoni A, et al. Recovery of left ventricular function following early reperfusion in acute myocardial infarction: a potential role for the calcium antagonist nisoldipine. Cardiovasc Drugs Ther 1997; 11:5-16.
10. Barsotti A, Napoli P. Trimetazidine and cardioprotection during ischemia-reperfusion Ital Heart J 2004; 5(Suppl 2):29S-36S.
11. Donato M, Gelpi RJ. Adenosine and cardioprotection during reperfusion – an overview. Mol Cell Biochem 2003; 251:153-159.
12. Siegfried MR, Erhardt J, Rider T, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther 1992; 260:668-675.
13. Klein HH, Pich S, Bohle RM, et al. Myocardial protection by Na(+)- H(+) exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995; 92:912-917.
14. Przyklenk K. Pharmacologic treatment of the stunned myocardium: the concepts and the challenges. Coron Artery Dis 2001; 12:363-369.
15. Pernow J, Wang QD. Endothelin in myocardial ischaemia and reperfusion. Cardiovasc Res 1997; 33:518-526.
16. Mannhold R. K-ATP channel openers: structure-activity relationships and therapeutic potential. Med Res Rev 2004; 24:213-266.
17. Pollesello P, Mebazaa A. ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction. Curr Opin Crit Care 2004; 10:436-441.
18. Auchampach JA, Maruyama M, Cavero I, et al. Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. Circulation 1992; 86:311-319.
19. Innes CA, Wagstaff AJ. Levosimendan: a review of its use in the management of acute decompensated heart failure. Drugs 2003; 63(23):2651-2671.
20. Rosevear PR, Finley N. Molecular mechanism of levosimendan action: an update. J Mol Cell Cardiol 2003; 35:1011-1015.
21. Ajiro Y, Hagiwara N, Katsube Y, et al. Levosimendan increases L-type Ca2+ current via phosphodiesterase – 3 inhibition in human cardiac myocytes. Eur J Pharmacol 2002; 435 (1):27-33.
22. Yokoshiki H, Katsube Y, Sunagawa M, et al. The novel calcium sensitizer levosimendan activates the ATP-sensitive K+ channel in rat ventricular cells. J Pharmacol Exp Ther 1997; 283:375-383.
23. Gruhn N, Nielsen-Kudsk JE, Theilgaard S, et al. Coronary vasorelaxant effect of levosimendan, a new inodilatador with calcium-sensitizing properties. J Cardiovasc Pharmacol 1998; 31:741-749.
24. Nieminen MS, Akkila J, Hasenfuss G, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000; 36:1903-1912.
25. Parissis JT, Adamopoulos S, Antoniades Ch, et al. Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure. Am J Cardiol 2004; 93:1309-1312.
26. Nieminen MS, Bohm M, Cowie MR, et al. Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the task Force on Acute Heart Failure of the European Society of Cardiology: ESC Committee for Practice Guidelines (CPG). Eur Heart J 2005; 26(4):384-416.
27. Follath F, Cleland JG, Just H, et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (The LIDO study): a randomised double-blind trial. Lancet 2002; 360:196-202.
28. Moiseyev VS, Poder P, Andrejevs N, et al. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAND). Eur Heart J 2002; 23:1422-1432.
29. Slawsky MT, Colucci WS, Gottlieb SS, et al. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators. Circulation 2000; 102:2222-2227.
30. Cleland JGF, Ghosh J, Freemantle N, et al. Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-LIPIDS and cardiac resynchronisation therapy in heart failure. Eur J Heart Failure 2004; 6:501-508.
31. Cleland JGF, Freemantle N, Coletta AP, et al. Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, an PROACTIVE. Eur J Heart Fail 2006; 8:105-110.
32. Sonntag S, Sundberg S, Lehtonen LA, et al. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 2004; 43:2177-2182.
33. Lehmann A, Lang J, Boldt J, et al. Levosimendan in patients with cardiogenic shock undergoing surgical revascularization: a case series. Med Sci Monit 2004; 10:89-93.
34. García González MJ, Domínguez Rodríguez A, Ferrer Hita JJ. Utility of levosimendan, a new calcium sensitizing agent, in the treatment of cardiogenic shock due to myocardial stunning in patients with ST elevation myocardial infarction: a series of cases. J Clin Pharmacol 2005; 45:704-708.

Título español
 Bibliografía
 Artículo completo
(exclusivo a suscriptores)
 Autoevaluación
  Tema principal en SIIC Data Bases
 Especialidades

  English title
  Abstract
  Key words
Full text
(exclusivo a suscriptores)


Autor 
Artículos
Correspondencia
Patrocinio y reconocimiento
Imprimir esta página
 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618