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Bruno Gonzalez-Zorn*
Autor invitado por SIIC

El trabajo alerta sobre la adquisición cromosómica de una metiltransferasa de resistencia a aminoglucósidos en una bacteria patógena

Cronicas de autores COSTO BIOLÓGICO E INTERFERENCIA ENTRE METILASAS ADQUIRIDAS Y ENDÓGENAS

En este trabajo observamos que la adquisición cromosómica de una metiltransferasa del ARNr 16S de resistencia a aminoglucósidos no supone un costo biológico adicional para la bacteria, metilando todos los ribosomas incluso en ausencia de antibióticos. Además, esta metilación desplaza metilaciones endógenas adyacentes altamente conservadas a lo largo de la evolución.
*Bruno Gonzalez-Zorn
describe para SIIC los aspectos relevantes de su trabajo
FITNESS COST AND INTERFERENCE OF ARM/RMT AMINOGLYCOSIDE RESISTANCE WITH THE RSMF HOUSEKEEPING METHYLTRANSFERASES

Antimicrobial Agents and Chemotherapy,
56(5):2335-2341

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.
Institución principal de la investigación
*Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, España
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Referencias bibliográficas
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Otros artículos de Bruno Gonzalez-Zorn
Gutiérrez B, Douthwaite S, González Zorn B. Indigenous and acquired modifications in the aminoglycoside binding sites of Pseudomonas aeruginosa rRNAs. RNA Biology 10(8):1324-32, 2013.
Gutiérrez B, Herrera León S, Escudero JA, Hidalgo L, González Sanz R, Arroyo M, San Millán A, Echeita MA, González Zorn B. Novel genetic environment of qnrB2 associated with TEM-1 and SHV-12 on pB1004, an IncHI2 plasmid, in Salmonella Bredeney BB1047 from Spain. J Antimicrob Chemother 64:1334-6, 2009.
San Millán A, Escudero JA, Gutiérrez B, Hidalgo L, García N, Llagostera M, Domínguez L, González Zorn, B. Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. Antimicrob Agents Chemother 53:3399-404, 2009.
Hidalgo L, Hopkins KL, Gutiérrez B, Ovejero CM, Shukla S, Douthwaite S, Prasad KN, Woodford N, González Zorn B. Association of the novel aminoglycoside resistance determinant RmtF with NDM carbapenemase in Enterobacteriaceae isolated in India and the UK. J Antimicrob Chemother 68:1543-50, 2013.
Hidalgo L, Gutiérrez B, Ovejero CM, Carrilero L, Matrat S, Saba CKS, Santos López A, Thomas López D, Hoefer A, Santurde G, Martín Espada C, González Zorn B. Klebsiella pneumoniae ST11 from companion animals bearing ArmA methyltransferase, DHA-1 beta-lactamase and QnrB4. Antimicrob Agents Chemother 57:4532-34, 2013.
Autor invitado
16 de julio, 2012
Descripción aprobada
24 de septiembre, 2015
Reedición siicsalud
7 de julio, 2017

Acerca del trabajo completo
COSTO BIOLÓGICO E INTERFERENCIA ENTRE METILASAS ADQUIRIDAS Y ENDÓGENAS
Título original en castellano
COSTE BIOLÓGICO E INTERFERENCIA DE LAS METILASAS DE RESISTENCIA DE LA FAMILA ARM/RMT CON LA METILASA ENDÓGENA RSMF
Autores
Bruno Gonzalez-Zorn1, Belen Gutierrez2
1 Profesor de Universidad, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, España, Director de Departamento
2 Veterinario, Facultad de Veterinaria, Universidad Complutense de Madrid, Investigadora Postdoctoral
Acceso a la fuente original
Antimicrobial Agents and Chemotherapy
http://aac.asm.org/

Acceso al texto original completo (full text)
http://aac.asm.org/content/56/5/2335.long

Acceso al resumen/abstract original
http://www.ncbi.nlm.nih.gov/pubmed/?term=Fitness+Cost+and+Interference+of+Arm%2FRmt+Aminoglycoside+Resistance+with+the+RsmF+Housekeeping+Methyltransferases

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