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The cardiac changes that could happen in non cardiac patients with intractable epilepsy were studied. The serum levels measurement of a novel cardiac marker namely, the Heart type fatty acid binding protein were performed and indicated an increase in both the ictal and the inter-ictal phases, as well as changes detected at the analysis of the ictal and the inter-ictal electrocardiographic changes in such patients. Through our results we cast the light on the possibility of a sort of asymptomatic cardiac ischemia that could accompany intractable epilepsy. - SIIC