EFECTO ANTIMICROBIANO DEL OXIDO NITRICO





EFECTO ANTIMICROBIANO DEL OXIDO NITRICO

(especial para SIIC © Derechos reservados)
Se han realizado algunos estudios que muestran el efecto antimicrobiano del óxido nítrico, pero no acerca de su interacción con antibióticos y microorganismos.
Autor:
Ahmet Yilmaz Coban
Columnista Experto de SIIC
Artículos publicados por Ahmet Yilmaz Coban
Recepción del artículo
11 de Febrero, 2007
Aprobación
23 de Marzo, 2007
Primera edición
28 de Septiembre, 2007
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
El óxido nítrico (NO) es una molécula efectora biológica con una amplia gama de actividades. En los macrófagos funciona como un potente agente microbicida que destruye los microorganismos ingeridos. En este artículo, se explica el efecto antimicrobiano del NO y su interacción entre los antibióticos y los microorganismos.

Palabras clave
óxido nítrico, microorganismos, efecto antimicrobiano


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Abstract
Nitric oxide (NO) is a biologic effector molecule with a broad range of activities. In macrophages, it functions as a potent microbicidal agent that kills ingested organisms. In this article, antimicrobial effect of NO and interaction of NO between antimicrobials and microorganisms were discussed.

Key words
nitric oxide, microorganisms, antimicrobial effect


Full text
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Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Infectología
Relacionadas: Bioquímica, Farmacología, Medicina Interna



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Enviar correspondencia a:
Ahmet Yilmaz Coban, Ondokuz Mayis University Department of Microbiology and Clinical Microbiology, Medical School, 55139, Samsun, Turquía
Bibliografía del artículo
1. Kuby J. Immunology, third edition, W.H. Freeman and Company, pp. 65-67, 1997.
2. Alam MS, Zaki MH, Yoshitake J, Akuta T, Ezaki T, Akaike T. Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection. Microb Pathogen 40:116-125, 2006.
3. Alam MS, Akaike T, Okamoto S et al. Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun 70:3130-3142, 2002.
4. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Eng J Med 329:2002-2012, 1993.
5. Ghaffari A, Miller CC, McMullin B, Ghahary A. Potential application of gaseous nitric oxide as a topical antimicrobial agent. Nitric Oxide 14:21-29, 2006.
6. Long R, Light B, Talbot JA. Mycobacteriocidal action of exogenous nitric oxide. Antimicrob Agents Chemother 43:403-405, 1999.
7. Granger DL, Hibbs JB, Perfect Jr. JR, Durack DT. Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages. J Clin Investig 81:1129-1136, 1988.
8. James SL. Role of nitric oxide in parasitic infections. Microbiol Rev 59:533-547, 1995.
9. Nathan C. Inducible nitric oxide synthase: what difference does it make? J Clin Investig 100:2417-2423, 1997.
10. Nathan C, Shiloh UM. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 97:8841-8848, 2000.
11. Brunelli L, Crow JP, Beckman JS. The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli. Arch Biochem Biophys 316:327-334, 1995.
12. DeGroote MA, Granger D, Xu Y, Campbell G, Prince R, Fang FC. Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model. Proc Natl Acad Sci USA 92:6399-6403, 1995.
13. Kuwahara H, Miyamoto Y, Akaike T et al. Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production. Infect Immun 68:4378-4383, 2000.
14. Jean D, Maitre B, Tankovic J et al. Beneficial effects of nitric oxide inhalation on pulmonary bacterial clearance. Crit Care Med 30:442-447, 2002.
15. DeGroote MA, Fang FC. NO inhibitions: Antimicrobial properties of nitric oxide. Clin Infect Dis 21(Suppl 2):S162-S165, 1995.
16. Coban AY, Durupinar B. The effect of nitric oxide combined with fluoroquinolones against Salmonella enterica serovar Typhimurium in vitro. Mem Inst Oswaldo Cruz 98:419-423, 2003.
17. McElhaney-Feser GE, Raulli RE, Cihlar RL. Synergy of nitric oxide and azoles against Candida species in vitro. Antimicrob Agents Chemother 42:2342-2346, 1998.
18. Fitzhugh AL, Keefer LK. Diazeniumdiolates: Pro- and antioxidant applications of the "NONOates". Free Radic Biol Med 28:1463-1469, 2000.
19. Coban AY, Bayramoglu G, Ekinci B, Durupinar B. Investigation of antibacterial effect of nitric oxide. Mikrobiyol Bul 37:151-155 (In Turkish), 2003.
20. Coban AY, Durupinar B. The investigation of the efficacy of nitric oxide against Mycobacterium tuberculosis in vitro. OMU Tip Derg 19:191-194 (In Turkish), 2002.
21. Coban AY, Ekinci B, Birinci A, Durupinar B. Investigation of the susceptibilities of rapidly growing non-tuberculosis mycobacteria to nitric oxide donor DETA-NO. Mikrobiyol Bul 35:513-517 (In Turkish), 2001.
22. Ghaffari A, Neil DH, Ardakani A, Road J, Ghahary A, Miller CC. A direct nitric oxide gas delivery system for bacterial and mammalian cell cultures. Nitric Oxide 12:129-140, 2005.
23. McMullin BB, Chittock DR, Roscoe DL, Garcha H, Wang L, Miller CC. The antimicrobial effect of nitric oxide on the bacteria that cause nosocomial pneumoniae in mechanically ventilated patients in the intensive care unit. Respir Care 50:1451-1456, 2005.

 
 
 
 
 
 
 
 
 
 
 
 
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