Paula Ruybal *

Autora invitada por SIIC

ESTRATEGIA PARA LA OPTIMIZACION DE LA EXPRESION DE GENES TERAPEUTICOS EN LINFOMAS T

Numerosos grupos de investigación alrededor del mundo se encuentran evaluando protocolos de terapia génica para el tratamiento de diferentes enfermedades. Entre éstas se encuentra el cáncer, que luego de las enfermedades cardiovasculares representa la segunda causa de muerte en la población mundial.

*Paula Ruybal
describe para SIIC los aspectos relevantes de su trabajo
TRANSGENE EXPRESSION ENHANCEMENT IN T-LYMPHOMA CELL LINES
Institución principal de la investigación
*Centro de Estudios Farmacológicos y Botánicos, Cefybo-conicet, Buenos Aires, Argentina, Buenos Aires, Argentina
Imprimir nota

Referencias bibliográficas
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4. Zarrin AA, Malkin L, Fong I, Luk KD, Ghose A, Berinstein NL. Comparison of CMV, RSV, SV40 viral and Vl1 cellular promoters in B and T lymphoid and non-lymphoid cell lines. Biochim Biophys Acta 1996; 1446:135-139.
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7. Mongini C, Ruybal P, Gravisaco MJ, Croci M, Sa´nchez Lockhart M, Fabris V, et al. Characterization of the immunophenotype and the metastatic properties of a murine T-lymphoma cell line. Unexpected expression of cytoplasmatic CD4. In vitro Cell Dev Biol-Animal 2001; 37:499-504.
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18. Wilkinson GWG, Akrigg A. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucleic Acids Res 1992; 30:2233-2239.
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Otros artículos de Paula Ruybal

Gravisaco MJ, Mongini C, Ruybal P, Escalada A, Sánchez Lockhart M, Alvarez E, Hajos SE, Waldner C. IL-2, IL-10, IL-15 and TNF are key regulators of a murine T-cell lymphoma growth. Int J Molecular Medicine 2003, 12(4):627-632.

Barcala V, Ruybal P, García Rivello H, Waldner C, Ascione A, Mongini C. TRANCE expression in haematological B malignancies. A report in follicular lymphoma. Eur J Haematology, 2003; 70:417-419.

Mongini C, Ruybal P, Gravisaco MJ, Croci M, Sánchez Lockhart M, Fabris V, Waldner C. Characterization of the immunophenotype and the metastatic properties of a murine T-lymphoma cell line. Unexpected expression of cytoplasmatic CD4. In Vitro Cell Dev Biol Animal 2001; 37:499-504.

Mongini C, Ruybal P, García Rivello H, Mocetti E, Escalada A, Christiansen S, Argibay P. Apoptosis in gut-associated lymphoid tissue (GALT): A response to injury or a physiologic mechanism? Transplantation Proceedings 1998; 30(6):2673-2676.

Para comunicarse con Paula Ruybal mencionar a SIIC como referencia:
pruybal@cicv.inta.gov.ar

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Acerca del trabajo completo

ESTRATEGIA PARA LA OPTIMIZACION DE LA EXPRESION DE GENES TERAPEUTICOS EN LINFOMAS T

Título original en castellano
Aumento de la expresion de un transgen en lineas celulares de derivadas de linfomas T

Autor
Paula Ruybal¹, María José Gravisaco², Virna Barcala³, Ana Escalada⁴, Graciela Cremaschi⁵, Oscar Taboga⁶, Claudia Waldner⁷, Claudia Mongini⁸
1 Lic. en Ciencias Biológicas, Instituto de Biotecnología, Cicvya, Instituto Nacional de Tecnología Agropecuaria, Becaria Posdoctoral
2 Bioquímica, Laboratorio de Inmunología Molecular y Celular, Centro de Estudios Farmacológicos, Becaria Posdoctoral
3 Bioquímica, Citomlab, Hospital Italiano de Buenos Aires
4 Bioquímica, Citomed, Buenos Aires, Argentina
5 Bioquímica, Laboratorio de Neuroinmunomodulación, Centro de Estudios Farmacológicos y Botánicos, Investigadora del Conicet
6 Lic. en Ciencias Biológicas, Instituto de Biotecnología, Centro de Investigación en Ciencias Veterinarias, Investigador del Conicet
7 Bioquímica, Laboratorio de Inmunología Molecular y Celular, Centro de Estudios Farmacológicos, Investigadora del Conicet
8 Bioquímica, Laboratorio de Inmunología Molecular y Celular, Centro de Estudios Farmacológicos, Investigadora del Conicet

Acceso a la fuente original
International Immunopharmacology
http://www.sciencedirect.com/science/journal/15675769