Conceptos Categóricos

GENETICA DA DEPENDENCIA DO ALCOOL

GENETICA DA DEPENDENCIA DO ALCOOL

(especial para SIIC © Derechos reservados)
Fatores genéticos estão implicados na vulnerabilidade à dependência do álcool. Essa ação se expressa, do ponto de vista biológico, por fatores complexos, provavelmente envolvendo variantes biológicas dopaminérgicas e do metabolismo do álcool.
messas9.jpg Autor:
Guilherme Peres Messas
Columnista Experto de SIIC
Artículos publicados por Guilherme Peres Messas
Coautor
Homero Vallada-Filho* 
Livre-Docente, Universidade Federal do São Paulo, São Paulo, Brasil*
Recepción del artículo
26 de Noviembre, 2006
Aprobación
4 de Enero, 2007
Primera edición
19 de Febrero, 2007
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Este artigo procura examinar a questão da herdabilidade na dependência do álcool. Estudos em famílias, em gêmeos e de adoção, apresentam evidências suficientes para afirmar a importância dos fatores genéticos na transmissão da vulnerabilidade a esta dependência. Essa transmissão pode ser melhor compreendida através de um modelo epigenético de desenvolvimento do transtorno, no qual condições biológicas hereditárias associem-se a situações ambientais ao longo da vida para a produção da dependência. Neste artigo, apresentamos essas condições biológicas intermediárias vinculadas ao alto risco para dependência do álcool. Por fim, descrevemos os estudos moleculares que vêm estabelecendo associações entre polimorfismos e a dependência do álcool, com relevo para o sistema dopaminérgico.

Palabras clave
dependência do álcool, genética molecular, vulnerabilidade ao álcool, modelo epigenético, receptores dopaminérgicos


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Abstract
In this article we examined the heritability of alcohol dependence. A review of family, twin and adoption studies, allowed us to support the thesis of an important genetic component in this dependence. The transmission of this heritability occurs through a biological vulnerability associated to environmental factors, in a model called epigenetic. We also discussed the relationship between biological vulnerability and high-risk phenotypes for alcohol dependence. In the end, we briefly comment on the molecular genetic studies associated with this disorder.

Key words
alcohol dependence, molecular genetics, alcohol vulnerability, epigenetic model, dopaminergic receptors


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Toxicología
Relacionadas: Genética Humana, Medicina Interna, Salud Pública



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Enviar correspondencia a:
Guilherme Peres Messas, Unidade de Álcool e Drogas (UNIAD), Universidade Federal de São Paulo, Rua Joaquim Floriano 871 cj. 124, São Paulo, Brasil
Bibliografía del artículo
1. Merikangas K, Stolar M, Stevens D, O'Malley S, Rousanville B. Familial transmission of substance use disorders. Arch Gen Psychiatry 1998; 55:973-9.
2. Van den Bree M, Johonson E, Neale M, Pickens R. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 1998; 52:231-41.
3. Kendler K, Prescott C. Cocaine use, abuse and dependence in a population-based sample of female twins. Brit J Psychiatry 1998; 173:345-50.
4. Cadoret R, Yates W, Troughton E, Woodworth G, Stewart M. Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 1995; 52:42-52.
5. Moss H, Black T, Martin C, Tarter R. Heightened motor activity level in male offspring of substance abuse fathers: association with temperament, behavior and psychiatric diagnosis. Biol Psichiatry 1992; 32:1125-47.
6. Sher K, Walitzer K, Wood P, Brent E. Characteristics of children of alcoholics: putative risk factors, substance use and abuse, and psychopathology. J Abnormal Psychology 1991; 100:427-88.
7. Finn P, Zeitouni N, Pihl R. Effects of alcohol on psychophysiological hyperactivity to nonaversive and aversive stimuli in men at high risk for alcoholism. Journal Ab Psychology 1990; 9:79-85.
8. Wall T, Shea S, Luczak C, Cook T, Carr L. Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. Journal Ab Psychology 2005; 114(3):456-65.
9. Cook T, Luczak C, Shea S, Ehlers C, Carr L, Wall T. Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans. J Stud Alcohol 2005; 66(2):196-204.
10. Schuchkit M. Biological, psychological, and environmental predictors of the alcoholism risk: a longitudinal study. J Stud Alcohol 1998; 59:485-94.
11. Comings D, Wu S, Dietz G, Muhleman D. Polygenic inheritance of Tourette Syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder. Am J Med Gen (Neuropsychiatric Genetics) 1996; 67:264-88.
12. Blum K, Noble E, Sharidan P, Montgomery A, Ritchie T, Cohon J. Allelic association of human dopamine D2 receptor gene and alcoholism. JAMA 1990; 263(15):2055-60.
13. Bolos A, Dean M, Lucas-Derse C, Ramsburg M, Brown G, Goldman D. Popultion and pedigree studies reveal a lack of association between the dopamine D2 receptor and alcoholism. JAMA 1990; 264(24):3156-60.
14. Gelernter J, O'Malley S, Risch N, Kranzler H, Krystal J, Merikangas K, Kennedy J, Kidd K. No association between na allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 1991; 266(13):1801-7.
15. Comings D, Gade R, Wu S, Chiu C, Muhleman D, Saucier G, Ferry L, Rosenthal R, Lesleur H, Rugle L, MacMurray P. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Mol Psychiatry 1997; 2:44-56.
16. Noble E. The dopamine D2 receptor gene: a review of association studies in alcoholism and phenotypes. Alcohol 1998; 16(1):33-45.
17.Ponce G, Jiménez Arriero M, Rubio G, Hoenicka J, Ampuero I, Ramos J, Palomo T. The A1 allele of the DRD2 gene (TaqI A polymorphism) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur Psychiatry 2003; 18(7):356-60.
18. Noble E, Berman S, Ozkaragoz T, Ritchie T. Prolonged P300 latency in children with D2 dopamine receptor A1 allele. Am J Hum Genet 1994; 54:658-68.
19. Pohjalainen T, Rinne J, Nagren K, Lehikoinen P, Anttila K, Syvallahti E, Hietala J. The Al allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol Psychiatry 1998; 3(3):256-60.
20. Noble E, Gottschalk L, Fallon J, Ritchie T, Wu J. D2 dopamine receptor polymorphism and brain regional glucose metabolism. Am J Med Genet 1997; 74(2):162-6.
21. Thome J, Weijers H, Wiesbeck G, Sian J, Nara K, Boning J, Riederer P. Dopamine D3 receptor gene polymorphism and alcohol dependence: relation to personality rating. Psychiatr Genet 1999; 9(1):17-21.
22. Parsian A, Chakraverty S, Fisher L, Cloninger C. No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism. Am J Med Genet 1997; 74(3):281-5.
23. Kottler M, Cohen H, Segman R, Gritsenko I, Nemanov L, Lerer B, Kramer I, Zer-Zion M, Kletz I, Ebstein R. Excess dopamine D4 receptor (DRD4) exon III seven repeat allele in opioid-dependent subjects. Mol Psychiatry 1997; 2(3):251-4.
24. Vanyukov M, Moss H, Gioio A, Hughes H, Kaplan B, Tarter R. An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study. Behavior Genetics 1998; 28(2):75-82.
25. Kranzler H, Gelernter J, O'Malley S, Hernandez-Avila C, Kaufman D. Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1). Alcohol Clin Exp Res 1998; 22(6):1359-62.
26. Berretini W, Hoehe M, Ferraro T, DeMaria P, Gottheil E. Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse. Addict Biol 1997; 2:303-8.
27. Bergen A Kokosza J, Peterson R, Long J, Virkkunen M, Linnoila M, Goldman D. Mu opioid receptor gene variants: lack of association with alcohol dependence. Mol Psychiatry 1997; 2:490-4.
28. Sander T, Gscheidel N, Wendel B, Samochowiec J, Smolka M, Rommelspacher H, Schmidt L, Hoce M. Human mu opioid receptor variation and alcohol dependence. Alcohol Clin Exp Res 1998; 22(9):2108-10.
29. Sander T, Ball D, Murray R, Patel J, Samochowiec J, Winterer G, Rommelspacher H, Schimdt L, Loh E. Association analysis of sequence variants of GABA(A) alpha6, beta2, and gamm2 gene cluster and alcohol dependence. Alcohol Clin Exp Res 1999; 23(3):427-31.
30. Parsian A, Cloninger C. Human GABAA receptor alpha 1 and alpha 3 subnits genes and lcoholism. Alcohol Clin Exp Res 1997; 21(3):430-3.
31. Dick D, Plunkett J, Wetherill L, Xuei X, Goate A, Hesselborck V, et al. Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample. Alcohol Clin Exp Res 2006; 30(7):1101-10.
32. Dick D, Agrawal A, Schuckit M, Bierut L, Hinrichs A, Fox L. et al. Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. J Stud Alcohol 2006; 67(2):185-94.
33. Noble E, Zhang X, Ritche T, Lawford B, Grosser S, Young R, Sparkes R. D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. Psychiatr Res 1998; 81(2):133-47.
34. Schuckit M, Mazzanti C, Smith T, Ahmed U, Radel M, Iwata N, Goldman D. Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 1999; 45(5):647-51.

 
 
 
 
 
 
 
 
 
 
 
 
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