Maria de Nazaré Correia Soeiro *

Autor invitado por SIIC

Através do uso de um modelo de cultivo primário de cardiomiócitos, o presente estudo contribuiu para um melhor entendimento sobre as alterações na via endocítica de células cardíacas frente a sua interação com Trypanosoma cruzi

TRYPANOSOMA CRUZI MODULA A VIA ENDOCÍTICA DE CARDIOMIÓCITOS IN VITRO

Células cardíacas infectadas pelo Trypanosoma cruzi apresentam perda de atividade endocítica possivelmente associada á regulação negativa de GTPases, tais como Rab7 e Rab11 (compartimentos endocíticos tardios e de reciclagem, respectivamente), e de moléculas efetoras como a EEA1, relacionada à Rab5a (envolvida no transporte entre compartimentos endocíticos iniciais).

*Maria de Nazaré Correia Soeiro
describe para SIIC los aspectos relevantes de su trabajo
TRYPANOSOMA CRUZI MODULATES THE EXPRESSION OF RABS AND ALTERS THE ENDOCYTOSIS IN MOUSE CARDIOMYOCYTES IN VITRO
Institución principal de la investigación
*Fundação Oswaldo Cruz, Rio de Janeiro, Brasil
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Otros artículos de Maria de Nazaré Correia Soeiro

1. Souza EM, Menna-Barreto R, Araújojorge TC, Kumar A, Hu Q, Boykin DW, Soeiro M. Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi. Parasitology (London), 2006; 133:75-79.
2. Souza EM, Boykin DW, Oliveira GM, Kumar A, Hu Q, Soeiro M. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. JAC. In press, 2006.
3. Hespanhol RC, Soeiro M, Meirelles MNL, Batista MM, Côrtereal S. The expression of mannose-receptors in the skin fibroblast and their involvement in Leishmania (L.) amazonensis invasion. Journal of Histoichemistry and Cytochemistry 2005; 53(1):35-44.
4. Soeiro M, Souza EM, Stephens CE, Boykin DW. Aromatic diamidines as antiparasitic agents. Expert Opinion on Investigational Drugs 2005; 14(8):957-972.
5. Waghabi M, Keramidas M, Bailly S, Degrave W, Mendonça-Lima L, Soeiro M, Meirelles MNL, Paciornik S, Araújojorge TC, Feige JJ. Uptake of host cell transforming growth factor-b by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion. The American Journal of Pathology 2005; 167(4):993-1003.
6. Souza EM, Pons AH, Bailly C, Lansiaux A, Araújojorge TC, Soeiro M. Enzymatic markers for detection of cellular injury in primary cultures of mice cardiomyocytes. Memórias do Instituto Oswaldo Cruz 2004; 99(7):697-701.
7. Souza EM, Lansiaux A, Bailly C, Wilson W, Hu Q, Boykin DW, Batista MM, Araújojorge TC, Soeiro M. Phenyl substitution of furamidine markedly potentiates its antiparasitic activity against Trypanosoma cruzi and Leishmania (L) amazonensis. Biochemical Pharmacology 2004; 68(4):593-600.
8. Souza EM, Araújojorge TC, Bailly C, Lansiaux A, Batista MM, Oliveira GM, Soeiro M. Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models. Cell Tissue & Research 2003; 314(2):223-235.
9. Waghabi M, Coutinho CML, Soeiro M, Feige JJ, Minoprio P, Leuven FV, Araújojorge TC. Increased Trypanosoma cruzi invasion and heart fibrosis development is associated with high TGF -levels in mice deficient in alpha-2-macroglobulin. Infection and Immunity 2002; 70:5115-5123.
10. Soeiro M, Mota RA, Batista DGJ, Pereira MCS, Meirelles MNS. Trypanosoma cruzi infection impairs zymosam uptake by cardiomyocytes. Pathobiology 2002; 70:69-75.

Para comunicarse con Maria de Nazaré Correia Soeiro mencionar a SIIC como referencia:
soeiro@ioc.fiocruz.br

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Acerca del trabajo completo

TRYPANOSOMA CRUZI MODULA A VIA ENDOCÍTICA DE CARDIOMIÓCITOS IN VITRO



Autor
CF Silva¹, RA Mota², Maria de Nazaré Correia Soeiro³, Denise da Gama Jaen Batista⁴
1, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
2, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
3, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil, Pesquisador
4, FIOCRUZ, Rio de Janeiro, Brasil, Estudante

Acceso a la fuente original
Journal of Histochemistry & Cytochemistry
http://www.jhc.org/