C Romero-López *

NUEVOS ARN INHIBIDORES DE VHC OBTENIDOS POR SELECCION IN VITRO

El método de selección molecular in vitro desarrollado constituye una potente herramienta terapéutica que permite la obtención de nuevos ARN antivirales.

*C Romero-López
describe para SIIC los aspectos relevantes de su trabajo
INTERFERING WITH HEPATITIS C VIRUS IRES ACTIVITY USING RNA MOLECULES INDENTIFIED BY A NOVEL IN VITRO SELECTION METHOD
Institución principal de la investigación
*Instituto de Parasitología y Biomedicina ´López-Neyra´, Granada, España
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Referencias bibliográficas
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Barroso del Jesús A, Tabler M, Berzal Herranz A. (1999). Comparative kinetic analysis of structural variants of the hairpin ribozyme reveals further potential to optimize its catalytic performance. Antisense Nucleic Acid Drug Dev 9:433-440.
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Puerta Fernández E, Barroso del Jesús A, Romero López C, Berzal Herranz A. (2003a). HIV-1 TAR as anchoring site for optimized catalytic RNAs. Biol Chem 384:343-350.
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Otros artículos de C Romero-López

Barroso del Jesús A, Puerta Fernández E, Romero López C, Berzal Herranz A. (2004). An experimental method for selecting effective target sites and designing hairpin ribozymes. Methods Mol Biol 252:313-325.

Puerta Fernández E, Barroso del Jesús A, Romero López C, Berzal Herranz A. (2003a). HIV-1 TAR as anchoring site for optimized catalytic RNAs. Biol Chem 384, 343-350.

Puerta Fernández E, Barroso del Jesús A, Romero López C, Tapia N, Martínez MA, Berzal Herranz A. (2005). Inhibition of HIV-1 replication by RNA targeted against the LTR region. Aids 19:863-870.

Puerta Fernández E, Romero López C, Barroso del Jesús A, Berzal Herranz A. (2003b). Ribozymes: recent advances in the development of RNA tools. FEMS Microbiol Rev 27:75-97.

Romero López C, Barroso del Jesús A, Puerta Fernández E, Berzal Herranz A. (2004). Design and optimization of sequence-specific hairpin ribozymes. Methods Mol Biol 252:327-338.

Romero López C, Barroso del Jesús A, Puerta Fernández E, Berzal Herranz A. (2005). Interfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method. Biol Chem 386:183-190.

Barroso del Jesús A, Puerta Fernández E, Tapia N, Romero López C, Sánchez Luque FJ, Martínez MA, Berzal Herranz A. (2005) Inhibition of HIV-1 replication by an improved hairpin ribozyme that includes an RNA decoy. Acepted for publication.

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Acerca del trabajo completo

NUEVOS ARN INHIBIDORES DE VHC OBTENIDOS POR SELECCION IN VITRO

Título original en castellano
MOLECULAS DE ARN IDENTIFICADAS POR UN NUEVO METODO DE SELECCION IN VITRO QUE INTERFIEREN CON LA ACTIVIDAD DEL IRES DEL VIRUS DE LA HEPATITIS C

Autor
Cristina Romero López¹, Alicia Barroso del Jesús², Elena Puerta Fernández³, Alfredo Berzal Herranz⁴
1 Estudiante de Doctorado, Instituto de Parasitología y Biomedicina López Neyra, Estudiante
2 Investigadora, Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones, Investigadora Contratada
3 Investigadora, Universidad de Yale, Investigadora Posdoctoral
4 Investigador, Instituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones, Investigador Científico

Acceso a la fuente original
Biological Chemistry
http://dx.doi.org/10.1515/bc

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