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Federico Orozco *

Autor invitado por SIIC

La insuficiencia suprarrenal relativa es frecuente en pacientes cirróticos estables que presentan un mayor deterioro de la función hepática.

PREVALENCIA DE LA INSUFICIENCIA SUPRARRENAL RELATIVA Y SUPERVIVENCIA EN PACIENTES CON CIRROSIS ESTABLE

La insuficiencia suprarrenal relativa es frecuente en pacientes cirróticos estables que presentan un mayor deterioro de la función hepática, debiendo ser considerado como complicación de la enfermedad debido a la disminución en la supervivencia de los pacientes que presentan este trastorno endocrino. Por otra parte, debe considerarse el cortisol salival como una alternativa en el diagnóstico, ya que existe correación entre sus niveles con los del cortisol plasmático basal.

*Federico Orozco
describe para SIIC los aspectos relevantes de su trabajo
INSUFICIENCIA SUPRARRENAL RELATIVA EN PACIENTES CIRRÓTICOS
Medicina (Buenos Aires),
76(4):208-212 Jul, 2016

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital Alemán de Buenos Aires, Ciudad de Buenos Aires, Argentina
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Referencias bibliográficas
1. Maxime V, Lesur O, Annane D. Adrenal insufficiency in septic shock. Clin Chest Med 30:17-27, 2009.
2. Cooper M, Stewart P. Corticosteroid insufficiency in acutely Ill patients. N Engl J Med 348:727-34, 2003.
3. Bornstein S. Predisposing factors for adrenal insufficiency. N Engl J Med 360:2328-39, 2009.
4. Marik PE, Pastores SM, Annane D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36(6):1937-49, 2008.
5. Hamrahian A, Oseni T, Arafah B. Measurements of serum free cortisolin critically Ill patients. N Engl J Med 350:1629-38, 2004.
6. Marik P, Gayowski T, Starzl T. The hepatoadrenal syndrome: A common yet unrecognized clinical condition [on behalf of for the Hepatic Cortisol Research and Adrenal Pathophysiology Study Group] Crit Care Med 33(6): 1254-1259, 2005.
7. De Jong M, Beishuizen A, Spijkstra J, Groeneveld J. Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock. Crit Care Med 35(8), 2007.
8. Harry R, Auzinger G, Wendon J. The clinical importance of adrenal insufficiency in acute hepatic dysfunction. Hepatology 36:395-402, 2002.
9. Tsai MH, Peng YS, Chen YC, et al. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 43:673-681, 2006.
10. Fernandez J, Escorsell A, Zabalza M, et al. Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival. Hepatology 44:1288-1295, 2006.
11. Fede G, Spadaro L, Tomaselli T, et al. Assessment of adrenocortical reserve in stable patients with cirrhosis. Journal of Hepatology 54:243-250, 2011.
12. Galbois A, Rudler M, Massard J, et al. Assessment of adrenal function in cirrhotic patients: Salivary cortisol should be preferred. Journal of Hepatology 52:839-845, 2010.
13. Pecori Giraldi F, Ambrogio AG, De Martín M, Fatti L, Scacchi M, Cavagnini F. Specificity of first-line test for the diagnosis of Cushing´ Syndrome: Assessment in large series. J Clin Endocrinol Metab 92(11):4123-4129, 2007.
14. Putignano P, Toja P, Dubini A, Pecori Giraldi F, Corsello SM, Cavagnini F. Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening test for Cushing's syndrome. J Clin Endocrinol Metab 88(9):4153-4157, 2003.
15. Baid S, Sinaii N, Wade M, Rubino D, Nieman L. Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: A comparison of assay to establish hypercortisolism. J Clin Endocrinol Metab 92(8):3102-3107, 2007.
16. Kurd Zerikly R, Amiri L, Faiman C, et al. Diagnostic characteristics of late-night salivary cortisol using liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 95(10):4555-4559, 2010.
17. Raff H. Utility of salivary cortisol measurements in Cushing´s Syndrome and adrenal insufficiency. J Clin Endocrinol Metab 94(10):3647-3655, 2009.
18. Hung PD, Sterling RK. Predicting outcome of critically ill patients with cirrhosis admitted to the intensive care unit. J Clin Gastroenterol 37:203-205 167, 2003.
19. Cholongitas E, Senzolo M, Patch D, et al. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit. Aliment Pharmacol Ther 23:883-893, 2006.
20. Tsai MH, Chen YC, Ho YP, et al. Organ system failure scoring system can predict hospital mortality in critically ill cirrhotic patients. J Clin Gastroenterol 37:251-257, 2003.
21. Cholongitas E, Senzolo M, Patch D, et al. Scoring systems for assessing prognosis in critically ill adult cirrhotics. Aliment Pharmacol Ther 24:453-464, 2006.
22. O'Beirne J, Holmes M, Agarwal B, et al. Adrenal insufficiency in liver disease - What is the evidence? Journal of Hepatology 47:418-423, 2007.
23. Borzio M, Salerno F, Piantoni L, et al. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis 33:41-48, 2001.
24. Theocharidou E, Krag A, Bendtsen F, Moller S, Burroughs A. Cardiac dysfunction in cirrhosis - does adrenal function play a role? Liver Int 32(9):1327-1327, 2012.
25. Ratanarat R, Cazzavillan S, Ricci Z, et al. Usefulness of a molecular strategy for the detection of bacterial DNA in patients with severe sepsis undergoing continuous renal replacement therapy. Blood Purif 25:106-111, 2007.
26. Ruiz-del-Arbol L, Monescillo A, Arocena C, et al. Circulatory function and hepatorenal syndrome in cirrhosis. Hepatology 42:439-47, 2005.
27. Acevedo J, Fernández J, Prado V, Silva A, et al. Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis,hepatorenal syndrome, and death. Hepatology 58(5):1757-65, 2013.
28. Dunn JF, Nisula BC, Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53:58-68, 1981.
29. Ekins R. Measurement of free hormones in blood. Endocr Rev 11:5-46, 1990.
30. Mendel CM. The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10:232-274, 1989.
31. Mendel CM, Kuhn RW, Weisiger RA, et al. Uptake of cortisol by the perfused rat liver: validity of the free hormone hypothesis applied to cortisol. Endocrinology 124:468-476, 1989.
32. Mendel CM, Miller MB, Siiteri PK, Murai JT. Rates of dissociation of steroid and thyroid hormones from human serum albumin. J Steroid Biochem Mol Biol 37:245-250, 1990.
33. Davidson JS, Bolland MJ, Croxson MS, Chiu W, Lewis JG. A case of low cortisol-binding globulin: use of plasma free cortisol in interpretation of hypothalamic-pituitary-adrenal axis tests. Ann Clin Biochem 43:237-239, 2006.
34. Raff H, Raff JL, Findling JW. Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 83(8):2681- 2686, 1998.
35. Deutschbem T, Broecker-Preuss M, Flitsch F, et al. Salivary cortisol as a diagnostic tool for hyper and hypocortisolism improved screening by an automated immunoassay. Endocrine Reviews 32 (03_Meeting Abstracts) P3-569, 2001.
36. Carrasco C, García M, Goycochea M, et al. Reproducibility of late-night salivary cortisol using an automated immunoassay system and performance of one or two sample in the diagnosis of Cushing Syndrome. Endocrine Reviews 32 (03_Meeting Abstracts) P3-570, 2011.


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