Juan Ureña López *

Autor invitado por SIIC

El presente trabajo describe un mecanismo novedoso de regulación del diámetro arterial en el que participan los canales de Ca2+ tipo L y la ruta de sensibilización RhoA/ROCK

REGULACIÓN METABOTRÓPICA DE RHOA/RHO QUINASA POR LOS CANALES DE CA2+ TIPO L: NUEVO MECANISMO PARA LA CONTRACCIÓN ARTERIAL EN MAMÍFEROS INDUCIDA POR LA DESPOLARIZACIÓN

Los canales de Ca2+ tipo L del músculo liso vascular tienen una doble función en el control del diámetro arterial. Además de permitir la entrada de Ca2+ del medio externo, estos canales pueden activar, a través de una vía metabotrópica, la ruta RhoA/ROCK y favorecer el mantenimiento de la contracción.

*Juan Ureña López
describe para SIIC los aspectos relevantes de su trabajo
METABOTROPIC REGULATION OF RHOA/RHO-ASSOCIATED KINASE BY L-TYPE CA2+ CHANNELS: NEW MECHANISM FOR DEPOLARIZATION-EVOKED MAMMALIAN ARTERIAL CONTRACTION
Institución principal de la investigación
*Universidad de Sevilla, Sevilla, España
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Referencias bibliográficas
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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature.1997;389:990-994.

2. Abernethy DR, Schwartz JB.
Calcium-antagonist drugs. N Engl J Med. 1999;341:1447-1457.

3. Del Valle-Rodríguez A, Lopez-Barneo J, Ureña J. Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx. EMBO J. 2003;22:4337-4345.

4. Del Valle-Rodríguez A, Calderón E, Ruiz M, Ordoñez A, López-Barneo J, Ureña J.
Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction. Proc Natl Acad Sci USA. 2006;103:4316-4321.

5. Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J, López-Barneo J.
Genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle. Circ Res. 2010;106:1285-1289.

6. Fernández-Tenorio M, Porras-González C, Castellano A, del Valle-Rodríguez A,López-Barneo J and Ureña J. Metabotropic Regulation of RhoA/Rho-Associated Kinase By L-type Ca2+ Channels: New Mechanism for depolarization-Evoked Mammalian Arterial Contraction Circ Res 2011;108:1348-1357.

7. Kitazawa T, Gaylinn BD, Denney GH, Somlyo AP. G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain hosphorylation. J Biol Chem. 1991;266:1708-1715.

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Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J. 2002;364:431-440.

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Ca2+-dependent activation of Rho and Rho-kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res. 2003;93:548-556.

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High blood pressure upregulates arterial L-type Ca2+ channels: is membrane depolarization the signal? Circ Res. 2004;94:e97-104.

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Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation. 2002;105:1545-1547.

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Otros artículos de Juan Ureña López

1. López-Barneo J, López-López JR, Ureña J and González C.
Chemotransduction in the Carotid Body: K+ Current Modulated by PO2 in Type I Chemoreceptor Cells.Science 1988; 241:580-582.

2. Ureña J, López-López JR, González C and López-Barneo J.
Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body. J Gen Physiol 1989; 93: 979-999.

3. Ureña J, Fernández-Chacón R, Rodríguez-Benot A, Alvarez de Toledo G and López-Barneo J.
Hypoxia induces voltage dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells. Proc Natl Acad Sci (USA) 1994; 91:10208-10211.

4. Franco-Obregón A, Ureña J. and López-Barneo J.
Oxigen sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation.Proc Natl Acad Sci (USA) 1995; 2:4715-4719.

5. Ureña J, Franco-Obregón A and López-Barneo J.
Contrasting effects of hypoxia on cytosolic Ca2+ spikes in conduit and resistance myocytes of the rabbit pulmonary artery. J Physiol 1996; 496:103-109

6. del Valle-Rodríguez A, López-Barneo J and Ureña J.
Ca2+ channel-sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx EMBO J 2003;22:4337-4345.

7. del Valle-Rodríguez A, Calderón E, Ruiz M, Ordóñez A, López-Barneo J and Ureña J.
Metabotropic Ca2+ channel-induced Ca2+ release and ATP-dependent facilitation of arterial myocyte contraction. Proc Natl Acad Sci (USA) 2006;103:4316-432.

8. Calderón-Sánchez E, Fernández-Tenorio M, Ordóñez A, López-Barneo J, Ureña J.
Hypoxia inhibits vasoconstriction induced by metabotropic Ca2+ channel-induced Ca2+ release in mammaliam coronary arteries. Cardiov Res 2009; 82:115-124.

9. Fernández-Tenorio M, González-Rodríguez P, Porras C, Castellano A, Moosmang S, Hofmann F, Ureña J and López-Barneo J.
Genetic ablation of L-type Ca2+ channels abolishes depolarization-induced Ca2+ release in arterial smooth muscle Circ Res 2010;106: 1285-1289.

10. Fernández-Tenorio M, Porras-González C, Castellano A, del Valle-Rodríguez A, López-Barneo J and Ureña J.
Metabotropic Regulation of RhoA/Rho-Associated Kinase By L-type Ca2+ Channels: New Mechanism for Depolarization-Evoked Mammalian Arterial Contraction. Circ Res 2011;108:1348-1357.

Para comunicarse con Juan Ureña López mencionar a SIIC como referencia:
jurena@us.es

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Acerca del trabajo completo

REGULACIÓN METABOTRÓPICA DE RHOA/RHO QUINASA POR LOS CANALES DE CA2+ TIPO L: NUEVO MECANISMO PARA LA CONTRACCIÓN ARTERIAL EN MAMÍFEROS INDUCIDA POR LA DESPOLARIZACIÓN

Título original en castellano
REGULACION METABOTROPICA DE RHOA/RHO QUINASA POR LOS CANALES DE CA2+ TIPO L: NUEVO MECANISMO PARA LA CONTRACCION ARTERIAL EN MAMIFEROS INDUCIDA POR LA DESPOLARIZACION

Autor
Juan Ureña López¹, Miguel Fernandez Tenorio², Cristina Porras González³
1 Profesor, Universidad de Sevilla, Sevilla, España, Catedrático Universidad de Sevilla
2
3

Acceso a la fuente original
Circulation Research
http://circres.ahajournals.org

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