Authors' Reports

Andrew Marriot
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describe para SIIC los aspectos relevantes de su artículo

Effect of NAC on human cognition

N-acetylcysteine has been investigated for efficacy in modulating human cognition in a variety of clinical samples. We performed a systematic review of these studies and found some evidence for efficacy.

The article was published by
El artículo fue publicado por
Neuroscience and Biobehavioral Reviews
Volume / Volumen: 78
Number / Número:
First and last pages / Páginas inicial-final: 44-56
Year / Año: 2017
Month / Mes: july

Principal institution where the research took place
Institución principal de la investigación
Barwon Health, Geelong, Victoria, Australia

Authors' Report

Crónica del Autor

Efectos de la NAC sobre la Función Cognitiva en los Seres Humanos

En diversas muestras clínicas se evaluó la eficacia de la N-acetilcisteína sobre la modulación de la función cognitiva de los seres humanos. Se realizó una revisión sistemática de estos estudios y se encontraron indicios que avalan su eficacia.
Crónica del Autor

Imprimir nota

Bibliographic references
Referencias bibliográficas

Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology 57, 1515-1517, 2001.
Amen DG, Taylor DV, Ojala K, Kaur J, Willeumier K. Effects of brain-directed nutrients on cerebral blood flow and neuropsychological testing: a randomized, double-blind, placebo-controlled, crossover trial. Advances in Mind-Body Medicine 27:24-33, 2013.
Amen DG, Wu JC, Taylor D, Willeumier K. Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. Journal of Psychoactive Drugs 43:1-5, 2011.
Chan A, Paskavitz J, Remington R, Rasmussen S, Shea TB. Efficacy of a vitamin/nutraceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with an 16-month caregiver extension. American Journal of Alzheimer's Disease and Other Dementias 23:571-585, 2008.
Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. A vitamin/nutraceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. The Journal of Nutrition, Health & Aging 14:224-230, 2010.
Dean OM, Bush AI, Copolov DL, Kohlmann K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Berk M. Effects of N-acetyl cysteine on cognitive function in bipolar disorder. Psychiatry and Clinical Neurosciences 66:514-517, 2012.
Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic modulation of auditory information processing in the human brain. Biological Psychiatry 71:969-977, 2012.
Hauer K, Hildebrandt W, Sehl Y, Edler L, Oster P, Droge W. Improvement in muscular performance and decrease in tumor necrosis factor level in old age after antioxidant treatment. Journal of Molecular Medicine (Berlin, Germany) 81:118-125, 2003.
Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B. Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-blind, placebo controlled study. PLoS One 8, 2013.
Rapado-Castro M, Dodd S, Bush AI, Malhi GS, Skvarc DR, On ZX, Dean OM. Cognitive effects of adjunctive N-acetyl cysteine in psychosis. Psychological Medicine 1-11, 2016.
Remington R, Bechtel C, Larsen D, Samar A, Doshanjh L, Fishman P, Luo Y, Smyers K, Page R, Morell C, Shea TB. A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease. Journal of Alzheimer's Disease 45, 2015.
Remington R, Chan A, Paskavitz J, Shea TB. Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer's disease: a placebo-controlled pilot study. American Journal of Alzheimer's Disease and other Dementias 24:27-33, 2008.

Other articles written by the author Andrew Marriot
Otros artículos de Andrew Marriot

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Andrew Marriot was invited by SIIC on
Andrew Marriot fue invitado por SIIC el
2018, october 19
  The authors' report was accepted on
La crónica del autor fue aprobada el
2022, september 20
The authors' report was accepted on
La crónica del autor fue aprobada el
2022, september 20
Published in siicsalud
Publicado en siicsalud
2022, december 19

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Neurología
Mental Health
/ Salud Mental

and secondarily related to the following sections

y secundariamente con las siguientes secciones




Neurodegenerative Diseases
Enfermedades Degenerativas

Clinical Psychiatry
Psiquiatría Clínica de Adultos


Information about the full text
Acerca del trabajo completo

The Effect of N-Acetylcysteine (NAC) on Human Cognition - A Systematic Review

Author / Autor
David Skvarc1, Laura Gray2

2 Dr, Deakin University, Geelong, Australia

Access to the original source
Neuroscience and Biobehavioral Reviews

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