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Sahar Nejat
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

They are effective, but should be used with caution.

The prevalence of positive interferon-gamma release assays is correlated to the occurrence of active tuberculosis, which varies widely among migrant children of different backgrounds. More accurately than tuberculin skin tests, they identify those with tuberculosis infection and are effective for screening of migrants. Urgent, active cases may present within weeks after arrival and need clinical recognition.

The article was published by
El artículo fue publicado por
Acta Paediatrica
Volume / Volumen: 105
Number / Número: 6
First and last pages / Páginas inicial-final: 671-675
Year / Año: 2016
Month / Mes: june

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Astrid Lindgrens Barnsjukhus, Karolinska Universitetssjukhuset, Stockholm, N/A, Sweden

Authors' Report

Crónica del Autor

Ensayos de Liberación de Interferón Gamma para el Rastreo de la Tuberculosis en Niños Inmigrantes

La prevalencia de resultados positivos en los ensayos de liberación de interferón gamma se correlaciona con la presencia de tuberculosis activa, y varía ampliamente entre los niños inmigrantes de diferentes nacionalidades. Estos ensayos son más precisos que las pruebas cutáneas con tuberculina para la identificación de los pacientes con infección tuberculosa y son eficaces para el rastreo de los inmigrantes. Pueden aparecer casos activos en el transcurso de algunas semanas después del ingreso al país de acogida y, en ellos, urge el reconocimiento clínico.
Crónica del Autor

Imprimir nota

Bibliographic references
Referencias bibliográficas

Aldridge RW, Yates TA, Zenner D, White PJ, Abubakar I, Hayward AC. Pre-entry screening programmes for tuberculosis in migrants to low-incidence countries: a systematic review and meta-analysis. Lancet Infect Dis 14:1240-1249, 2014.
Chee CB, Lim LK, Barkham TM, Koh DR, Lam SO, Shen L, et al. Use of a T cell interferon-gamma release assay to evaluate tuberculosis risk in newly qualified physicians in Singapore healthcare institutions. Infect Control Hosp Epidemiol 30:870-875, 2009.
Chiappini E, Bonsignori F, Accetta G, Boddi V, Galli L, Biggeri A, et al. Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a literature review. Int J Immunopathol Pharmacol 25:335-343, 2012.
Diel R, Goletti D, Ferrara G, Bothamley G, Cirillo D, Kampmann B, et al. Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur Respir J 37:88-99, 2011.
Hansted E, Andriuskeviciene A, Sakalauskas R, Kevalas R, Sitkauskiene B. T-cell-based diagnosis of tuberculosis infection in children in Lithuania: a country of high incidence despite a high coverage with bacille Calmette-Guerin vaccination. BMC Pulm Med 9:41, 2009.
Hardy AB, Varma R, Collyns T, Moffitt SJ, Mullarkey C, Watson JP. Cost-effectiveness of the NICE guidelines for screening for latent tuberculosis infection: the QuantiFERONTB Gold IGRA alone is more cost-effective for immigrants from high burden countries. Thorax 65:178-180, 2010.
Howley MM, Painter JA, Katz DJ, Graviss EA, Reves R, Beavers SF, et al. Evaluation of QuantiFERON-TB gold intube and tuberculin skin tests among immigrant children being screened for latent tuberculosis infection. Pediatr Infect Dis J 34:35-39, 2015.
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Pareek M, Watson JP, Ormerod LP, Kon OM, Woltmann G, White PJ, et al. Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and costeffectiveness analysis. Lancet Infect Dis 11: 435-444, 2011.
Sollai S, Galli L, De Martino M, Chiappini E. Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update. BMC Infect Dis 14(Suppl. 1):S6, 2014.
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Wassie L, Aseffa A, Abebe M, Gebeyehu MZ, Zewdie M, Mihret A, et al. Parasitic infection may be associated with discordant responses to QuantiFERON and tuberculin skin test in apparently healthy children and adolescents in a tuberculosis endemic setting, Ethiopia. BMC Infect Dis 13:265, 2013.
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Other articles written by the author Sahar Nejat
Otros artículos de Sahar Nejat

Bennet R, Eriksson M. Paediatric tuberculosis cases increased in Stockholm from 1971-2015 following the rising number of children with immigrant backgrounds. Acta Paediatrica, in press. Doi:10.1111/apa.13629.
Bennet R, Hamrin J, Rotzén Östlund M, Zweygberg Wigart B, Örtqvist Å, Eriksson M. Influenza epidemiology among hospitalized children in stockholm, sweden 1998-2014. Vaccine 34:3208-3302, 2016.
Claesson G, Bennet R, Petrini B, Eriksson M. Nerve dysfunction following surgical treatment of cervical non-tuberculous mycobacterial lymphadenitis in children. Acta Paediatr 100:299-302, 2011.
Eriksson M, Bennet R, Rotzén-Östlund M, Von Sydow M, Zweygberg Wirgart B. Population based rates of severe respiratory syncytial virus infection in children with and without risk factors; and outcome in a tertiary care setting. Acta Paediatr 91:593-598, 2002.
Gillman A, Berggren I, Bergström S-E, Wahlgren H, Bennet R. Primary tuberculosis infection in 35 children at a Swedish day care center. Pediatr Infect Dis J 27:1078-1082, 2008.
Kan B, Ghebremichael S, Bennet R, Berggren I, Bruchfeld J, Chryssanthou E, et al. Extensive transmission of an isoniazid-resistant strain of Mycobacterium tuberculosis in Sweden. Int J Tub Lung Dis 12:199-204, 2008.
Lindstrand A, Galanis I, Bennet R, Schollin-Ask L, Hultman-Dennison S, Blennow M, et al. Sinusitis and pneumonia hospitalization after introduction of pneumococcal conjugate vaccine. Pediatrics 2014; doi: 10.1542/peds.2013-4177:e1528-36.
Luthander J, Bennet R, Giske CG, Nilsson A, Eriksson M. The aetiology of paediatric bloodstream infections changes after pneumococcal vaccination and group B streptococcus prophylaxis. Acta Paediatr 104:933-939, 2015.
Rinder M, Tran AN, Bennet R, Brytting M, Cassel T, Eriksson M, et al. Burden of severe rotavirus disease leading to hospitalisation assessed in a prospective cohort study in Sweden. Scand J Infect Dis 46:294-302, 2014.
Thorstrand C, Belfrage E, Bennet R, Malmborg P, Eriksson M. Successful 10-day treatment of neuroborreliosis in children. Pediatr Infect Dis J 21:1142-1145, 2002.

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Sahar Nejat was invited by SIIC on
Sahar Nejat fue invitado por SIIC el
2016, december 29
  The authors' report was accepted on
La crónica del autor fue aprobada el
2017, december 26
The authors' report was accepted on
La crónica del autor fue aprobada el
2017, december 26
Published in siicsalud
Publicado en siicsalud
2018, march 26

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Infectious Diseases
/ Infectología
/ Pediatría

and secondarily related to the following sections

y secundariamente con las siguientes secciones


Public Health
Salud Pública

Information about the full text
Acerca del trabajo completo

Interferon-Gamma Release Assays Can Effectively Screen Migrants for the Tuberculosis Infection, But Urgent, Active Cases Need Clinical Recognition

Author / Autor
Sahar Nejat1

1 Dr, Astrid Lindgens Barnsjukhus, Karolinska Universitetssjukhuset, Estocolmo, Suecia, Dr

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Acta Paediatrica

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