ANTILEUKEMIA ACTIVITIES OF RETINOID AND ARSENIC

Authors' Reports

Takeaki Nitto
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describe para SIIC los aspectos relevantes de su artículo

ANTILEUKEMIA ACTIVITIES OF RETINOID AND ARSENIC

All-trans retinoic acid and arsenic trioxide are recently recognized as effective agents to treat acute promyelocytic leukemia. These two agents reduce leukemia cells followed by affecting the function of the PML-RAR alpha, an unusual molecule as a result of the t(15;17) chromosomal translocation.

The article was published by
El artículo fue publicado por

Journal of Pharmacological Sciences
Volume / Volumen: 126
Number / Número: 3
First and last pages / Páginas inicial-final: 179-185
Year / Año: 2014
Month / Mes: november

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Yokohama University of Pharmacy（横浜薬科大学）, Yokohama, Kanagawa, Japan

Authors' Report
Crónica del Autor
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Bibliographic references
Referencias bibliográficas

1. Lallemand-Breitenbach V, Jeanne M, Benhenda S, Nasr R, Lei M, Peres L, et al. Arsenic degrades PML or PML-RAR-alpha; through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol 10:547-555, 2008.
2. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, et al. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 101:5328-5335, 2004.
3. Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369:111-121, 2013.
4. Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, De Thé H. Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure. Nat Med 20:167-174, 2014.

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The authors' report was accepted on La crónica del autor fue aprobada el 2021, march 9	Published in siicsalud Publicado en siicsalud 2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Pharmacology
/ Farmacología

Haematology
/ Hematología

and secondarily related to the following sections
y secundariamente con las siguientes secciones

Pharmaceutical Medicine
Medicina Farmacéutica

Oncology
Oncología

Information about the full text
Acerca del trabajo completo

Molecular Mechanisms of the Antileukemia Activities of Retinoid and Arsenic

Author / Autor
Takeaki Nitto¹

1 Ph. D., Yokohama University Of Pharmacy（横浜薬科大学）, Yokohama, Japón, Professor

Access to the original source
Journal of Pharmacological Sciences

Article URL: / URL del artículo:
https://www.jstage.jst.go.jp/browse/jphs
URL of Abstract: / URL del abstract:
https://www.jstage.jst.go.jp/article/jphs/126/3/126_14R15CP/_article
URL of Abstract page in Medline: / URL del abstract en Medline:
http://www.ncbi.nlm.nih.gov/pubmed/25319615
siic DB: / siic DB:
http://www.siicsalud.com/main/distriprinrel.php

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