Conceptos Categóricos

Authors' Reports

Silke Bachmann
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

A meta-analysis of longitudinal studies from 1992 to 2012

Neurological soft signs (NSS) were considered to be a trait marker of schizophrenia, present in most patients. A total of 787 patients were examined longitudinally in 17 studies. In 13 studies a decrease of NSS was observed over time. This means that NSS can also adopt state characteristics.

The article was published by
El artículo fue publicado por
Frontiers in Psychiatry
Volume / Volumen:
Number / Número:
First and last pages / Páginas inicial-final: 0
Year / Año: 2014
Month / Mes: december

Principal institution where the research took place
Institución principal de la investigación
Klinik für Psychiatrie, Psychotherapie und Psychosomatik der Medizinischen Fakultät, Universität Halle-Wittenberg, Deutschland, Halle (Saale), Sachsen-Anhalt, Germany

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

Bachmann S, Bottmer C, Schröder S. Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry 162:2337-2343, 2005.
Bachmann S, Schröder J. Neurological soft signs in schizophrenia: a review on the state- versus trait-perspective. In preparation.
Boks MPM, Selten JP, Leask S, Van den Bosch RJ. The 2-year stability of neurological soft signs after a first episode of non-affective psychosis. European Psychiatry 21:288-290, 2006.
Buchanan RW, Koeppl P, Breier A. Stability of neurological signs with clozapine treatment. Biol Psychiatry 36:198-200, 1994.
Chen EYH, Hui CLM, Chan RCK, Dunn ELW, Miao MYK, Yeung WS, Wong CK, Chan WF, Tang WN. A 3-year prospective study of neurological soft signs in first episode schizophrenia. Schizophrenia Research 75:45-54, 2005.
Cuesta MJ, Jalon EG, Campos MS, Peralta V. Cognitive effectiveness of olanzapine and risperidone in first episode psychosis. BJP 194:439-445, 2009.
Emsley R, Turner HJ, Oosthuizen PP, Carr J. Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical and outcome correlates. Schizophrenia Research 75:35-44, 2005.
Mangot AG, Sawant NS. First episode schizophrenia: neurological abnormalities and prognosis. GJPSY 2013, ISSN 1433-1055.
Mayoral M, Bombin I, Zabala A, Robes O, Moreno D, Parellada M, Ruiz-Sancho A, Arango C. Neurological soft signs in adolescents with first-episode psychosis: two-year followup. Psychiatry Research 161:344-348, 2008.
Mayoral M, Bombin I, Castro-Fornieles J, Gonzales-Pinto A, Otero S, Parellada M, Moreno D, Baeza I, Graell M, Rapado M, Arango C. Longitudinal study of neurological soft signs in first-episode early-onset psychosis. J Child Psychol Psychiatry 53:323-331, 2012.
Mittal VA, Hasenkamp W, Sanfilipo M, Wieland S, Angrist B, Rotrosen J, Duncan EJ. Relation of neurological soft signs to psychiatric symptoms in schizophrenia. Schizophrenia Research 94:37-44, 2007.
Prikryl R, Ceskova E, Kasparek T, Kucerova H. Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia. European Psychiatry 22:449-504, 2007.
Prikryl R, Ceskova E, Tronerova S, Kasparek T, Prikrylova Kucerova H, Ustohal L, Venclikova S, Vrzalova M. Dynamics of neurological soft signs and its relationship to clinical course in patients with first-episode schizophrenia. Psychiatry Research 200:67-72, 2012.
Schröder J, Niethammer R, Geider FJ, Reitz C. Binkert M, Jauss M, Sauer H. Neurological soft signs in schizophrenia. Schizophrenia Research 6:25-30, 1992.
Schröder J, Tittel A, Stockert A, Karr M. Memory deficits in subsyndromes of chronic schizophrenia. Schizophrenia Research 21:19-26, 1996.
Schröder J, Silvestri S, Bubeck B, Karr M, Demisch S, Scherrer S, Geider FJ, Sauer H. D2 Dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia: a follow-up study with 123I-iodobenzamide single photon emission computed tomography in the drug-naïve state and after neuroleptic treatment. Biol Psychiatry 43:660-665, 1998.
Sevincok L, Topaloglu B. Neurological soft signs and positive treatment response to olanzapine in chronic schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry 30:141-143, 2006.
Whitty P, Clarke M, Browne S, McTique O, Kamali M, Feeney L, Lane A, Kinsella A, Waddington JL, Larkin C, O'Callaghan E. Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena. Psychol Med 33:1479-84, 2003.

Other articles written by the author Silke Bachmann
Otros artículos de Silke Bachmann

Bachmann S, Degen C, Geider FJ, Schröder J. Neurological soft signs in the clinical course of schizophrenia: results of a metaanalysis. Frontiers in Psychiatry 5:185, 2014.
Kong L, Bachmann S, Thomann P, Essig M, Schröder J. Neurological soft signs and grey matter changes: a longitudinal analysis in first-episode schizophrenia. Schizophrenia Research 34:27-32, 2012.
Bachmann S, Haffer S, Viviani R. Comparison of two different statistical methods for the analysis of magnetization transfer ratio data: a study in schizophrenia patients. Schizophrenia Research 132:91-96, 2011.
Bachmann S, Rupp A, Röhrig M, Schröder J, Scherg M, Weisbrod. MEG does not reveal impaired sensory gating in first episode schizophrenia. Schizophrenia Research 121:131-8, 2010.
Bachmann S, Bottmer C, Schröder J. One year outcome and its prediction in first-episode schizophrenia - a naturalistic study. Psychopathology 41:115-123, 2008.
Bachmann S, Bottmer Ch, Essig M, Magnotta V, Schröder J. Compliance with medication but not structural MRI measures predict functional outcome in first-episode schizophrenia patients. Schizophrenia Research 90:355-356, 2007.
Bachmann S, Bottmer C, Schröder J. Neurological soft signs in first-episode schizophrenia - a follow-up study. American Journal of Psychiatry 162:1-7, 2005.
Bachmann S, Bottmer C, Pantel J, Amann M, Essig M, Schad LR, Schröder J. MRI-morphometric changes in first-episode schizophrenic patients at 14 months follow-up. Schizophrenia Research 67:301-303, 2004.
Bachmann S, Pantel J, Flender A, Bottmer C, Essig M, Schröder J: Corpus callosum in first-episode patients with schizophrenia - a magnetic resonance imaging study. Psychological Medicine 33:1019-1027, 2003.
Karlsson H, Bachmann S, Schröder J, McArthur J, Torrey EF, Yolken RH. Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proceedings of the National Academy of Science 98(8):4634-4639, 2001.

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Silke Bachmann was invited by SIIC on
Silke Bachmann fue invitado por SIIC el
2015, february 13
  The authors' report was accepted on
La crónica del autor fue aprobada el
2018, april 13
The authors' report was accepted on
La crónica del autor fue aprobada el
2018, april 13
Published in siicsalud
Publicado en siicsalud
2018, july 12

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Imaging Diagnosis
/ Diagnóstico por Imágenes
Mental Health
/ Salud Mental

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Medical Education
Educación Médica


Information about the full text
Acerca del trabajo completo

Neurological Soft Signs in the Clinical Course of Schizophrenia: Results of a Meta-Analysis

Author / Autor
Silke Bachmann1, Christina Degen2, Franz Josef Geider3, Johannes Schröder4

4 Professor, Section Of Geriatric Psychiatry, Institute Of Gerontology, University Of Heidelberg, Heidelberg, Germany, Professor

Access to the original source
Frontiers in Psychiatry

Article URL:
/ URL del artículo:

URL of Abstract:
/ URL del abstract:

URL of Abstract page in Medline:
/ URL del abstract en Medline:

URL of Abstract page in Scielo:
/ URL del abstract en Scielo:

URL of Abstract page in Scopus:
/ URL del abstract en Scopus:

URL of Abstract page in Embase:
/ URL del abstract en Embase:

Other data bases:
/ Otras bases de datos:

siic DB:
/ siic DB: