Authors' Reports

Wissam Bleibel
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo


A high percentage of patients with chronic liver disease progresses to cirrhosis complicated by hepatic encephalopathy (HE). This presents with neurological impairments ranging from subclinical dysfunction to coma. Its management is based on eliminating the precipitating factors and decreasing the toxin load with adequate bowel motions or altering bowel flora.

The article was published by
El artículo fue publicado por
Saudi Journal of Gastroenterology
Volume / Volumen: 18
Number / Número: 5
First and last pages / Páginas inicial-final: 301-309
Year / Año: 2012
Month / Mes: september

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
University of Virginia, Charlottesville, VA, United States

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

Balata S, et al. Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis. Hepatology 37(4):931-9, 2003.
Bass NM, et al. Rifaximin treatment in hepatic encephalopathy. N Engl J Med 362(12):1071-81, 2010.
Bismuth M, et al. Hepatic encephalopathy: from pathophysiology to therapeutic management. Eur J Gastroenterol Hepatol 23(1):8-22.
Blauenfeldt RA, et al. Abnormal brain processing in hepatic encephalopathy: evidence of cerebral reorganization? Eur J Gastroenterol Hepatol 22(11):1323-30.
Blei AT, Cordoba J. Hepatic Encephalopathy. Am J Gastroenterol 96(7):1968-76, 2001.
Butterworth RF. Editorial: rifaximin and minimal hepatic encephalopathy. Am J Gastroenterol. 106(2):317-8.
Cadranel JF, et al. Focal neurological signs in hepatic encephalopathy in cirrhotic patients: an underestimated entity? Am J Gastroenterol 96(2):515-8, 2001.
Cordoba J, et al. Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol 41(1):38-43, 2004.
Kato T, et al. Therapeutic effect of balloon-occluded retrograde transvenous obliteration on portal-systemic encephalopathy in patients with liver cirrhosis. Intern Med 40(8):688-91, 2001.
Kircheis G, et al. Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy. Metab Brain Dis 17(4):453-62, 2002.
McPhail MJ, et al. Pathogenesis and diagnosis of hepatic encephalopathy. Expert Rev Gastroenterol Hepatol 4(3):365-78.
Montgomery JY, Bajaj JS. Advances in the evaluation and management of minimal hepatic encephalopathy. Curr Gastroenterol Rep 13(1):26-33.
Mullen KD. The Treatment of Patients With Hepatic Encephalopathy: Review of the Latest Data from EASL 2010. Gastroenterol Hepatol (N Y) 6(7):1-16.
Nelson DC, McGrew Jr WR, Hoyumpa AM Jr. Hypernatremia and lactulose therapy. JAMA 249(10):1295-8, 1983.
Prakash R, Mullen KD. Mechanisms, diagnosis and management of hepatic encephalopathy. Nat Rev Gastroenterol Hepatol 7(9):515-25.
Reddy PV, Rama Rao KV, Norenberg MD. Inhibitors of the mitochondrial permeability transition reduce ammonia-induced cell swelling in cultured astrocytes. J Neurosci Res 87(12):2677-85, 2009.
Riggio O, et al. Peripheral and splanchnic indole and oxindole levels in cirrhotic patients: a study on the pathophysiology of hepatic encephalopathy. Am J Gastroenterol 105(6):1374-81, 2010.
Seyan AS, Hughes RD, Shawcross DL. Changing face of hepatic encephalopathy: role of inflammation and oxidative stress. World J Gastroenterol 16(27):3347-57.
Sharma P, et al. Prophylaxis of Hepatic Encephalopathy in Acute Variceal Bleed: A Randomized Controlled Trial of Lactulose versus no Lactulose. J Gastroenterol Hepatol.
Wright G, et al. Interorgan ammonia metabolism in liver failure: the basis of current and future therapies. Liver Int 31(2):163-75.

Other articles written by the author Wissam Bleibel
Otros artículos de Wissam Bleibel

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Wissam Bleibel was invited by SIIC on
Wissam Bleibel fue invitado por SIIC el
2012, october 26
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Gastroenterología
Internal Medicine
/ Medicina Interna

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Intensive Care
Cuidados Intensivos


Family Medicine
Medicina Familiar


Mental Health
Salud Mental

Information about the full text
Acerca del trabajo completo

Hepatic Encephalopathy

Author / Autor
Wissam Bleibel1

1 Md, 1. Division Of Gastroenterology And Hepatology, Department Of Medicine, University Of Virginia Health System, Charlottesville, Va, Usa. 2. Owensboro Health Regional Hospital/university Ofkentucky, Owensboro, Ky, Usa., Owensboro, EE.UU., Adjunct Assistant Professor

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Saudi Journal of Gastroenterology

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