REACTIVE OXYGEN SPECIES CONTROL SHP-2 DIMERIZATION AND ACTIVITY
SHP-2 dimerization is stabilized by the formation of disulfide bonds and it is modulated by growth factors and by the cellular redox state. Notably, the dimeric form is less active compared to its the monomeric self-inhibited counterpart pointing to dimerization as an additional mechanism to control SHP-2 activity.

Aurelio Pio Nardozza
Roma, IT

  

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  REACTIVE OXYGEN SPECIES CONTROL SHP-2 DIMERIZATION AND ACTIVITY
SHP-2 dimerization is stabilized by the formation of disulfide bonds and it is modulated by growth factors and by the cellular redox state. Notably, the dimeric form is less active compared to its the monomeric self-inhibited counterpart pointing to dimerization as an additional mechanism to control SHP-2 activity.

Aurelio Pio Nardozza
Roma, IT

  

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TROMBOFILIA Y COMPLICACIONES DEL EMBARAZO
Se describe el impacto de las trombofilias cong?nitas y adquiridas sobre el pron?stico de la gestaci?n, con ?nfasis en las complicaciones.

J Korin
Buenos Aires, Argentina

     

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IMPLANTACIÓN REDUCIDA EN EMBRIONES CON DIVISIÓN DIRECTA MEDIANTE IMÁGENES TIME-LAPSE
La presencia del fenómeno de división directa en los embriones de una cohorte condiciona el potencial de implantación de dichos embriones. Mediante tecnología time-lapse es posible detectar este fenómeno y así evitar la transferencia de los embriones que la presentan.

Irene Rubio Palacios
Valencia, España

     

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  QUALITY CONTROL AT THE ENDOPLASMIC RETICULUM TRANSLOCON
The essential Sec61 translocon brings proteins into and across the endoplasmic reticulum membrane. Little was known about how proteins blocking this channel are removed. New data reveal that the Hrd1 ubiquitin ligase degrades proteins that persistently and abnormally engage Sec61. This quality control pathway may also regulate low-density lipoprotein particle synthesis.

Eric Rubenstein
New Haven, US

  

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