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Santiago Ambrosio Viale *

Autor invitado por SIIC


LA DOPAMINA PUEDE AFECTAR LA VIABILIDAD CELULAR POR DESEQUILIBRIO REDOX

La neurodegeneración de las neuronas dopaminérgicas puede estar ocasionada por una alteración en el potencial redox intracelular desencadenada por un aumento de la DA citosólica, ya sea por alteraciones en su catabolismo o por algún defecto en su internalización en vesículas.

*Santiago Ambrosio Viale
describe para SIIC los aspectos relevantes de su trabajo
THE DECREASE OF NAD(P)H HAS A PROMINENT ROLE IN DOPAMINE TOXICITY
BBA Molecular Basis of Disease,
1762(5):564-574

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Universidad de Barcelona, Barcelona, España
Acerca del trabajo completo
THE DECREASE OF NAD(P)H HAS A PROMINENT ROLE IN DOPAMINE TOXICITY

Título original en castellano
LA DISMINUCION DE NAD(P)H TIENE UN PAPEL CLAVE EN LA TOXICIDAD DE LA DOPAMINA



Autores
Santiago Ambrosio Viale1, Pol Giménez Xavier2, Cristina Gómez Santos3, Ester Castaño4, Roser Francisco5, Jordi Boada6, Mercedes Unzeta7, Elisenda Sanz8
1 Profesor Universidad, Universidad de Barcelona, Profesor Titular
2 Biólogo, Departamento Ciencias Fisiológicas II, Universidad de Barcelona, Becario
3 Bióloga, Centro Investigaciones Enfermedades Neurodegenerativas, Barcelona, Técnico Superior
4 Bióloga, Servicios Científico-técnicos, Universidad de Barcelona, Técnico Superior
5 Bióloga, Departamento Ciencias Fisiológicas II, Universidad de Barcelona, Becaria
6 Farmacéutico, Departamento Ciencias Fisiológicas II, Universidad de Barcelona, Técnico Superior
7 Profesora Titular, Departamento Bioquímica y Biología Molecular, Universidad Autónoma de Barcelona, Vicerrectora
8 Bióloga, Departamento Bioquímica y Biología Molecular, Universidad Autónoma de Barcelona, Becaria


Acceso a la fuente original
BBA Molecular Basis of Disease
http://www.elsevier.com/wps/find/journaldescription.cws_home/506068/description
Referencias bibliográficas
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Autor invitado
10 de julio, 2006
Descripción aprobada
27 de julio, 2006
Reedición siicsalud
18 de enero, 2010
Otros artículos de Santiago Ambrosio Viale
Espejo M, Cutillas B, Arenas E, Ambrosio S. Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor. Cell Transplant 2000; 9:45-53.Boada J, Cutillas B, Roig T, Bermúdez J, Ambrosio S. MPP+-induced mitochondrial dysfunction is potentiated by dopamine. Biochem Biophys Res Commun 2000; 268:916-920.Gómez C, Reiriz J, Piqué M, Gil J, Ferrer I, Ambrosio S. Low concentrations of MPP+ induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells. J Neurosci Res 2001; 63:421-428.Gómez Santos C, Ferrer I, Reiriz J, Viñals F, Barrachina M, Ambrosio S. MPP+ increases a-synuclein expression and ERK/MAPK-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res 2002; 935:32-39.Gómez Santos C, Ambrosio S, Ventura F, Ferrer I, Reiriz J. TGF-ß1 increases tyrosine hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma by BMP-2 in human neuroblastoma SH-SY5Y cells. Brain Res 2002; 958:152-160.Gómez Santos C, Ferrer I, Santidrián AF, Barrachina M, Gil J, Ambrosio S. Dopamine induces autophagic cell death and alpha-synuclein increase in human neuroblastoma SH-SY5Y cells. J. Neurosci. Res 2003; 73:341-350.Dalfó E, Barrachina M, Rosa JL, Ambrosio S, Ferrer I. Abnormal -synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. Neurobiol Dis 2004; 16:92-97.Viñals F, Reiriz J, Ambrosio S, Bartrons R, Rosa JL, Ventura F. BMP-2 decreases mash1 staility by increasing Id1 expression. EMBO J 2004; 23:3527-3537.Gómez Santos C, Barrachina M, Giménez Xavier P, Dalfó E, Ferrer I, Ambrosio S. Induction of C/EBPß and GADD153 expression by dopamine in human neuroblastoma cells. Relationship with -synuclein increase and cell damage. Brain Res Bull 2005; 65:87-95.Gómez Santos C, Giménez Xavier P, Ferrer I, Ambrosio S. Intranigral dopamine toxicity and a-synuclein response in rats. Neurochem Res 2006; DOI: 10.1007/s11064-006-9090-2.


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