Aldo D. Mottino *

Autor invitado por SIIC

El intestino delgado, un órgano programado para absorber nutrientes, puede colaborar con el hígado en la función detoxificadora

IMPORTANCIA DE LA CAPACIDAD DETOXIFICADORA DEL INTESTINO EN LA INSUFICIENCIA HEPATICA

En la insuficiencia hepática otros tejidos podrían reemplazar al hígado, al menos en parte, en su función detoxificadora. Nuestro estudio provee evidencias en favor de un papel relevante del yeyuno en la metabolización y posterior excreción a la luz intestinal de xenobióticos potencialmente tóxicos.

*Aldo D. Mottino
describe para SIIC los aspectos relevantes de su trabajo
INVOLVEMENT OF MRP2 IN HEPATIC AND INTESTINAL DISPOSITION OF DINITROPHENYL-S-GLUTATHIONE IN PARTIALLY HEPATECTOMIZED RATS
Institución principal de la investigación
*Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Argentina, Rosario, Argentina
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Referencias bibliográficas
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Catania VA, Luquita MG, Sánchez Pozzi EJ, Mottino AD. (1998). Enhancement of intestinal UDP-glucuronosyltransferase activity in partially hepatectomized rats. Biochim. Biophys. Acta 1380, 345-353.
Catania VA, Sánchez Pozzi EJ, Luquita MG, Ruiz ML, Villanueva SM, Jones B, Mottino AD. (2004). Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2. Ann. Hepatol. 3, 11-17.
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Crocenzi FA, Mottino AD, Cao J, Veggi LM, Sánchez Pozzi EJ, Vore M, Coleman R, Roma MG. (2003). Estradiol-17-D-glucuronide induces endocytic internalization of Bsep in the rat. Am. J. Physiol. 285, G449-G459. (a)
Crocenzi FA, Mottino AD, Sánchez Pozzi EJ, Pellegrino JM, Rodríguez Garay EA, Milkiewicz P, Vore M, Coleman R, Roma MG. (2003). Impaired localisation and transport function of canalicular bsep in taurolithocholate-induced cholestasis in the rat. Gut 52, 1170-1177. (b)
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Otros artículos de Aldo D. Mottino

Crocenzi FA, Sánchez Pozzi EJ, Pellegrino JM, Favre CO, Rodríguez Garay EA, Mottino AD, Coleman R, Roma MG. Beneficial effects of silymarin on estrogen induced cholestasis in the rat. Hepatology 34:329-339.

Mottino AD, Hoffman T, Dawson P, Luquita MG, Monti JA, Sánchez Pozzi EJ, Catania VA, Cao J, Vore M. Increased expression of the ileal apical sodium-dependent bile acid transporter (ASBT) in postpartum rats. Am. J. Physiol. 282:G51-G60.

Veggi LM, Crocenzi FA, Roma MG, Dawson PA, Pellegrino JM, Sánchez Pozzi EJ, Mottino AD. Dapsone-induced cholestasis and impairment of bile salt output in the rat. Biochem. Pharmacol. 63:1553-1563.

Arriaga SM, Almará AM, Mottino AD. In vivo anticomplementary effect of bilirubin-IX alpha. Biochem. Pharmacol. 64:741-744.

Catania VA, Luquita MG, Sánchez Pozzi EJ, Ikushiro S, Emi Y, Iyanagi T, Mottino AD. Effect of spironolactone on the expresión of rat hepatic UDP-glucuronosyltransferase. Biochem Pharmacol 66:171-177.

Sánchez Pozzi EJ, Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, Rodríguez Garay EA, Mottino AD. Ursodeoxycholate reduces ethinylestradiol glucuronidation in the rat: role in prevention of estrogen-induced cholestasis. J. Pharmacol. Exp. Ther. 306:279-286.

Mottino AD, Veggi LM, Wood M, Vélez Román J, Vore M. Biliary secretion of glutathione in estradiol-17b-D-glucuronide-induced cholestasis. J. Pharmacol. Exp. Ther. 307:306-313.

Ghanem CI, Gómez PC, Arana MC, Perassolo M, Ruiz ML, Villanueva SSM, Ochoa EJ, Catania VA, Bengochea LA, Mottino AD. Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem. Pharmacol. 68:791-798.

Role of microtubules in estradiol-17-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Mottino AD, Crocenzi FA, Sánchez Pozzi EJ, Veggi LM, Roma MG, Vore M. Am. J. Physiol. 288:G327-G336.

Ruiz ML, Villanueva SSM, Luquita MG, Sánchez Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa EJ, Vore M, Mottino AD, Catania VA. Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2. Biochem. Pharmacol. 69:531-539.

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Acerca del trabajo completo

IMPORTANCIA DE LA CAPACIDAD DETOXIFICADORA DEL INTESTINO EN LA INSUFICIENCIA HEPATICA

Título original en castellano
PARTICIPACION DE MRP2 EN LA ELIMINACION HEPATICA E INTESTINAL DE DINITROFENIL-S-GLUTATION EN RATAS PARCIALMENTE HEPATECTOMIZADAS

Autor
Aldo D. Mottino¹
1 Doctor en Bioquímica, Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Profesor Asociado UNR, Investigador Principal

Acceso a la fuente original
Toxicological Sciences
http://www.toxsci.oupjournals.org

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