Mónica Hebe Vazquez-Levin *

Autor invitado por SIIC

El trabajo de investigación clínica realizado sobre más de 10.000 hombres en los que se evaluó su calidad seminal, demuestra una disminución en los valores de los parámetros espermáticos con la edad, así como con ciertas condiciones clínicas y estilos de

EL POTENCIAL FÉRTIL DEL HOMBRE DISMINUYE CON SU EDAD, ASÍ COMO CON LA OBESIDAD, EL CONSUMO DE ALCOHOL Y EL TABAQUISMO.

El incremento de la edad del hombre es un factor que, per se, afecta negativamente la calidad espermática. Además, la obesidad contribuye de forma importante al daño causado por la edad. El consumo de alcohol y el tabaquismo tienen un efecto negativo adicional al de la edad, aunque menor que el de la obesidad. Estos hallazgos son muy relevantes teniendo en cuenta la tendencia global a la postergación de la paternidad, el aumento en la obesidad y en el consumo de alcohol y tabaco.

*Mónica Hebe Vazquez-Levin
describe para SIIC los aspectos relevantes de su trabajo
IMPACT OF AGE, CLINICAL CONDITIONS, AND LIFESTYLE ON ROUTINE SEMEN PARAMETERS AND SPERM KINEMATICS
Institución principal de la investigación
*Instituto de Biología y Medicina Experimental (ibyme). Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (conicet)- Fundación Ibyme (fibyme), Ciudad Autónoma De Buenos Aire, Argentina
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Referencias bibliográficas
1. Lutz W. Fertility rates and future population trends: Will Europe's birth rate recover or continue to decline? Int J Androl 29:25-33, 2006.
2. Belloc S, Hazout A, Zini A, Merviel P, Cabry R, Chahine H, et al. How to overcome male infertility after 40: Influence of paternal age on fertility. Maturitas 78:22-9, 2014.
3. Statistics Denmark. Average age of women given birth and new fathers by age and time. Available at: https://www.statistikbanken.dk/statbank5a/SelectVarVal/Define.asp?Maintable=FOD11&PLanguage=1. Accessed September 21, 2017.
4. Office for National Statistics. Births by parent's characteristics in England and Wales: 2015. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthsbyparentscharacteristicsinenglandandwales/2015. Accessed September 21, 2017.
5. Kühnert B, Nieschlag E. Reproductive functions of the ageing male. Hum Reprod Update 10:327-339, 2004.
6. Van Roode T, Sharples K, Dickson N, Paul C. Life-course relationship between socioeconomic circumstances and timing of first birth in a birth cohort. PLoS One 12:e0170170, 2017.
7. Hout M. Social and economic returns to college education in the United States. Annu Rev Sociol 38:379-400, 2012.
8. Torr BM. The changing relationship between education and marriage in the United States, 1940-2000. J Fam Hist 36:483-503, 2011.
9. Mills M, Rindfuss RR, McDonald P, Te Velde E. ESHRE Reproduction and Society Task Force. Why do people postpone parenthood? Reasons and social policy incentives. Hum Reprod Update 17:848-860, 2011.
10. Schwartz D, Mayaux MJ. Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS. N Engl J Med 306:404-406, 1982.
11. Ford WC, North K, Taylor H, Farrow A, Hull MG, Golding J. Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 15:1703-1708, 2000.
12. Hassan MA, Killick SR. Effect of male age on fertility: evidence for thedecline in male fertility with increasing age. Fertil Steril 79(Suppl3):1520-1527, 2003.
13. Belloc S, Hazout A, Zini A, Merviel P, Cabry R, Chahine H, et al. How to overcome male infertility after 40: Influence of paternal age on fertility. Maturitas 78:22-29, 2014.
14. Johnson SL, Dunleavy J, Gemmell NJ, Nakagawa S. Consistent age-dependent declines in human semen quality: a systematic review and meta-analysis. Ageing Res Rev 19:22-33, 2015.
15. Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a Review of the literature. Fertil Steril 75:237-248, 2001.
16. Winkle T, Rosenbusch B, Gagsteiger F, Paiss T, Zoller N. The correlation between male age, sperm quality and sperm DNA fragmentation in 320 men attending a fertility center. J Assist Reprod Genet 26:41-46, 2009.
17. Stone BA, Alex A, Werlin LB, Marrs RP. Age thresholds for changes in semen parameters in men. Fertil Steril 100:952-958, 2013.
18. Beguería R, García D, Obradors A, Poisot F, Vassena R, Vernaeve V. Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers? Hum Reprod 29:2114-2122, 2014.
19. Colasante A, Minasi MG, Scarselli F, Casciani V, Zazzaro V, Ruberti A, Greco P, Varricchio MT, Greco E. The aging male: Relationship between male age, sperm quality and sperm DNA damage in an unselected population of 3124 men attending the fertility centre for the first time. Arch Ital Urol Androl 90:254-259, 2019.
20. Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, Petersen JH, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish Mmen. Fertil Steril 82:863-870, 2004.
21. Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, et al. BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221-231, 2013.
22. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: A systematic review with meta-analysis. Hum Reprod Update 16:293-311, 2010.
23. Condorelli RA, Calogero AE, Vicari E, La Vignera S. Chronic consumption of alcohol and sperm parameters: Our experience and the main evidences. Andrologia 47:368-379, 2015.
24. Keskin MZ, Budak S, Gubari S, Durmaz K, Yoldas M, Celik O, et al. Do cigarette and alcohol affect semen analysis? Arch Ital Urol Androl 88:56-59, 2016.
25. Anifandis G, Bounartzi T, Messini CI, Dafopoulos K, Sotiriou S, Messinis IE. The impact of cigarette smoking and alcohol consumption on sperm parameters and sperm DNA fragmentation (SDF) measured by Halosperm(®). Arch Gynecol Obstet 290:777-782, 2014.
26. Hamad MF, Shelko N, Kartarius S, Montenarh M, Hammadeh ME. Impact of cigarette smoking on histone (H2B) to protamine ratio in human spermatozoa and its relation to sperm parameters. Andrology 2:666-677, 2014.
27. World Health Organization. WHO Laboratory Manual for the Examination of Human Semen and Semen-Cervical Mucus Interaction, 5th ed. Cambridge University Press, 2010.
28. Goriely A, Wilkie AO. Paternal age effect mutations and selfish spermatogonial selection: cCauses and consequences for human disease. Am J Hum Genet 90:175-200, 2012.
29. Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, et al. Rate of De Novo Mutations and the Importance of Father's Age to Disease Risk. Nature (2012);488:471-5.
30. Choi JY, Lee KM, Park SK, Noh DY, Ahn SH, Yoo KY, Kang D. Association of paternal age at birth and the risk of breast cancer in offspring: A case control study. BMC Cancer 5:143, 2005.
31. Yip BH, Pawitan Y, Czene K. Parental age and risk of childhood cancers: a population-based cohort study from Sweden. Int J Epidemiol 35:1495-1503, 2006.
32. Toriello HV, Meck JM. Professional Practice and Guidelines Committee. Statement on guidance for genetic counseling in advanced paternal age. Genet Med 10:457-60, 2008.
33. Jenkins TG, Aston KI, Carrell DT. Sperm epigenetics and aging. Transl Androl Urol 7(Suppl 3):S328-S335, 2018.
34. Kimura R, Yoshizaki K, Osumi N. Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm. Adv Exp Med Biol 1012:75-81, 2018.

Otros artículos de Mónica Hebe Vazquez-Levin

Vázquez MH, Phillips D, Wassarman P. Interaction of mouse sperm with sperm receptors covalently linked to silica beads. J Cell Science 92:713-722, 1989.
Vázquez Levin MH, Reventos J, Gordon JW. Molecular cloning, sequencing and restriction mapping of the genomic sequence encoding human proacrosin. J Eur Biochem 207:23-26, 1992.
Vázquez Levin MH, Notrica JA, Polak de Fried E. Male immunological infertility: sperm performance on in vitro fertilization. Fertil Steril 68:675-681, 1997.
Furlong LI, Hellman U, Krimer A, Tezón JG, Charreau EH, Vázquez Levin MH. Expression of human proacrosin in Escherichia coli and binding to zona pellucida. Biol Reprod 62:606-615, 2000.
Marín Briggiler CI, Veiga MF, Matos ML, González- Echeverría MF, Furlong LI, Vázquez Levin MH. Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization.
Marín Briggiler CI, González Echeverría MF, Munuce MJ, Ghersevich S, Caille AM, Hellman U, Corrigall VM, Vázquez Levin MH. Glucose-regulated protein 78 (Grp78/BiP) is secreted by human oviduct epithelial cells and modulates sperm-zona pellucida binding. Fertil Steril 93:1574-84, 2010.
Marín Briggiler CI, Lapyckyj L, González Echeverría MF, Rawe VY, Alvarez Sedó C, Vázquez Levin MH. Neural cadherin is expressed in human gametes and participates in sperm-oocyte interaction events Int J Androl 33:e228-39, 2010.
Gabrielli NM, Veiga MF, Matos ML, Quintana S, Chemes HE, Blanco G, Vázquez Levin MH. Expression of dysadherin in the human male reproductive tract and in spermatozoa. Fertil Steril 96:554-561.e2, 2011.
García L, Veiga MF, Lustig L, Vázquez Levin MH, Veaute C. DNA immunization to proacrosin impairs fertilization in male mice. Am J Reprod Immunol 68:56-67, 2012.
Veron GL, Molina RI, Tissera AD, Estofan G, Marín Briggiler CI, Vázquez Levin MH. Incidence of sperm surface autoantibodies and relationship with routine semen parameters and sperm kinematics. Am J Reprod Immunol 76:59-69, 2016.

Para comunicarse con Mónica Hebe Vazquez-Levin mencionar a SIIC como referencia:
mhvazl@gmail.com

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Acerca del trabajo completo

EL POTENCIAL FÉRTIL DEL HOMBRE DISMINUYE CON SU EDAD, ASÍ COMO CON LA OBESIDAD, EL CONSUMO DE ALCOHOL Y EL TABAQUISMO.

Título original en castellano
IMPACTO DE LA EDAD, CONDICIONES CLINICAS Y ESTILOS DE VIDA EN LOS PARAMETROS SEMINALES Y EN LA CINEMATICA ESPERMATICA

Autor
Mónica Hebe Vazquez-Levin¹
1 Dra. en Ciencias Químicas de L, Instituto de Biología y Medicina Experimental (ibyme). Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (conicet)- Fundación Ibyme (fibyme), Ciudad Autónoma De Buenos Aire, Argentina, Investigadora Principal Conicet. Directo

Acceso a la fuente original
Fertility and Sterility
http://www.fertstert.org/

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