Crónicas de autores

Adriana Sampayo Reyes *

Autora invitada por SIIC

En este estudio por primera vez se muestra que el tocoferol succinato es un potente inhibidor de la hGSTO1-1.

INHIBICION DE LA GLUTATION S-TRANSFERASA OMEGA POR TOCOFEROL SUCCINATO

El tocoferol succinato es un potente inhibidor de la hGSTO 1-1. Esta investigación claramente indica que se trata de un compuesto sumamente efectivo y no tóxico para el ser humano. Los niveles de expresión de estas enzimas pueden tener significado biológico e implicaciones clínicas. Si estos inhibidores de la hGSTO1-1 resultan ser efectivos in vivo deberían realizarse más investigaciones en este contexto.

*Adriana Sampayo Reyes
describe para SIIC los aspectos relevantes de su trabajo
INHIBITION OF HUMAN GLUTATHIONE S-TRANSFERASE OMEGA BY TOCOPHEROL SUCCINATE
Biomedicine & Pharmacotherapy,
60(5):238-244 Jun, 2006

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Centro de Investigación Biomédicas del Noreste, Monterrey, México
Imprimir nota
Referencias bibliográficas
1. Townsend DM, Tew KD. The role of glutathione-S transferase in anticancer drug resistance. Oncogene 2003; 22:7369.
2. Hayes JD, McLellan LI. Gultathione and glutathione dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radical Res 1999; 31:273-300.
3. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J. Identification, characterization and crystal structure of Omega class glutathione transferase. J Biol Chem 2000; 275:24798-24806.
4. Dirr H, Reinemer P, Huber R. X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function. Eur J Biochem 1994; 220:645-661.
5. Sinning I, Kleywegt GJ, Cowan SW, Reinemer P, Dirr HW, Huber R, Gilliland GL, Armstrong RN, Ji X, Board PG, Olin B, Mannervik B, Jones TA. Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes. J Mol Biol 1993; 232:192-212.
6. Schmuck EM, Board PG, Whitbread AK, Tetlow N, Cavanaugh JA, Blackburn AC, Masoumi A. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Pharmacogenetics and Genomics 2005; 15(7):493-501.
7. Dulhunty A, Gage P, Curtis S, Chelvanayagam G, Board P. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. J Biol Chem 2001; 276:3319-3323.
8. Ishikawa T, Casini AF, Nishikimi M. Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase. J Biol Chem 1998; 273:28708-28712.
9. Kodym R, Calkins P, Story M. The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins. J Biol Chem 1999; 274:5131-5137.
10. Aposhian HV, Zakharyan RA, Avram MD, Sampayo Reyes A, Wollenberg ML. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicology and Applied Pharmacology 2004; 198:327-335.
11. Yin ZL, Dahlstrom JE, LeCouteur DG, Board PG. Immunohistochemistry of omega class glutathione S-transferase in human tissues. J Histochem Cytochem 2001; 49:983-988.
12. Sampayo Reyes A, Zakharyan RA, Healy SM, Aposhian HV. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem Res Toxicol 2000; 13:1181-1186.
13. Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, et al. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet 2003; 12:3259-3267.
14. Laliberte R.E., Perregaux DG, Lise R. Hoth, Rosner PJ, Jordan CK, Peese KM, Eggler FJ, Dombroski MA, Geoghegan KF and Gabel CA. Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1 posttranslational processing. The Journal of Biological Chemistry 2003; 278:16567-16578.
15. Kölsch H, Linnebank M, Lütjohann D, Jessen F, Wüllner U, Harbrecht U, Thelen KM, Kreis M. Hentschel F, Schulz A, Von Bergmann K, Maier W, Heun R. Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. Neurology 2004; 63:2255-2260.
16. Serrano Sánchez T, Díaz Armesto I. Participation of interleukin 1 and interleukin 6 in the aetiopathogenesis of Alzheimer's disease. Rev Neurol 2001; 33 (7):648-652.
17. Van Haaften RIM, Evelo CTA, Penders J, Eijnwachter MPF, Haenen GRMM. Bast A. Inhibition of human glutathione S-transferase P1-1 by tocopherols and alpha-tocopherol derivatives. Biochimica et Biophysica Acta 2001; 1548:23-28.
18. Azzi A. Stocker A. Vitamin E: non-antioxidant roles Prog Lipid Res 2000; 39:231-255.
19. Traber MG, Packer L. Vitamin E: beyond antioxidant function. Am J Clin Nutr 1995; 62:1501S-1509S.
20. Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996; 31:671-701.
21. Mulder GJ, Ouwerkerk-Mahadevan S. Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular system in vitro. Chemico-Biological Interactions 1997; 105:17-34.
22. Zakharyan R, Aposhian H V. Enzymatic reduction of arsenic compounds in
mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA (V) reductase. Chem Res Toxicol 1999; 12:1278-1283.
23. Whitbread AK, Tetlow N, Eyre HJ. Sutherland GR, Board PG. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics 2003; 13:131-144.
24. Zakharyan RA, Sampayo Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV. Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol 2001; 14:1051-1057.
25. Board PG, Coggan M, Johnson P, Ross V, Suzuki J, Webb G. Genetic heterogeneity of the human glutathione transferases: a complex of gene families. Pharmacol Ther 1990; 48:357-369.
26. Sheweita SA, Tilmisany AK. Cancer and phase drug-metabolizing enzymes. Current Drug Metabolism 2003; 4:45-58.
27. Kontush A, Schekatolina S. Vitamin E in neurodegenerative disorders Alzheimer's disease. Ann NY Acad Sci 2004; 1031:249-262.
Otros artículos de Adriana Sampayo Reyes

Morales Aguilera A, Jiménez Salas Z, Sampayo Reyes A. Changes in the protein profile of rats erythrocyte membranes produced by two myotonia inducers: clofibrate and anthracene-9-carboxylic acid. Biophysical Jr 1987; 51(2):568a.
Sampayo Reyes A, Morales Aguilera A, Mendoza Gamboa E. Effects of clofibrate on erythrocyte membranes. Proc West Pharmacol Soc 1991; 34:93.
Mendoza Gamboa E, Sampayo Reyes A, Morales Aguilera A. Presence of erythrocyte IgG auto-antibodies in clofibrate-treated rats. Proc West Pharmacol Soc 1991; 34:97.
Morales Aguilera A, Sampayo Reyes A. Molecular changes in erythrocyte membranes induced by long-term administration of clofibrate. European Journal of Pharmacology 1993; 245:89-95.
Bogdan GM, Sampayo Reyes A, Aposhian HV. Arsenic binding protein of mammalian systems I. Isolation of three arsenic binding proteins of rabbit liver. Toxicology 1994; 93:175-193.
Sampayo Reyes A, Morales Aguilera A. Temporal course of erythrocyte changes induced by clofibrate. Western Pharmacology Society 1995; 38:34.
Morales Aguilera A, Sampayo Reyes A, Muriel P, Favari. Biochemical changes in clofibrate modified erythrocyte membranes. Western Pharmacology Society 1995; 38:30.
Leal Garza CH, Sampayo Reyes A, Cortes EI. Estudio citogenético en parejas con aborto habitual. Antropología Biológica 1995; 3(2):29-42.
Sampayo Reyes A, Leal Garza CH, Cortes EI, Morales Aguilera A. Clofibrate induced changes in rat erythrocytes are dependent on duration of tratment. Pharmaceutical Sciences 1997; 3:407-410.
Sampayo Reyes A, Zakharyan RA, Healy SM, Aposhian VH. Monomethylarsonic acid reductase and monomethylarsonous acid hamster tissue. Chemical Research in Toxicology 2000; 13(11):1181-1186.
Zakharyan RA, Sampayo Reyes A, Healy SM, Tsapralis G, Board PG, Liebler DC, Aposhian HV. Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione S-transferase superfamily. Chem Res Toxicol 2001; 14:1051-1057.
Radabaugh T, Sampayo Reyes A, Zakharyan RA, Aposhian HV. 2002. Purine nucleoside phosphorylase in the presence od dhihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalians system. Chemical Research in Toxicology 15(5):692-8.
Cortés Gutiérrez EI, Cerda Flores RM, González Ramírez D, Zuniga Charles MA, Sampayo Reyes A, Martínez Lazcano S, Leal Garza CH. Mutagenic and cytotoxic effects of mercurous chloride evaluated by the micronuclei technique in vivo. Mutagenesis 2004; 19(3):203-205.
Aposhian HV, Zakharyan RA, Avram MD, Sampayo Reyes A, Wollenberg ML. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicology and Applied Pharmacology 2004; 198:327-335.
Sampayo Reyes A, Saíd Fernández S, Cortés Gutiérrez EI, Cerda Flores RM, Narro Juárez A, Lozano Garza HG, González Garza MT, Martínez Rodríguez HG, Vargas Villarreal J, Mata Cárdenas BD, Morales Aguilera A. Effect of clofibric acid on desmin and vimentin content in rat myocardiocytes. International Journal of Toxicology 2006; 25:5.
Sampayo Reyes A, Zakharyan RA. Inhibition of human glutathione s-transferase omega by tocopherol succinate. Biomedicine & Pharmacotherapy 2006; 60:238-244.

Para comunicarse con Adriana Sampayo Reyes mencionar a SIIC como referencia:
adriana.sampayo@biomedicas.net

Autora invitada
3 de agosto, 2006
Descripción aprobada
13 de octubre, 2006
Reedición siicsalud
7 de junio, 2021

Acerca del trabajo completo
INHIBICION DE LA GLUTATION S-TRANSFERASA OMEGA POR TOCOFEROL SUCCINATO



Autor
Adriana Sampayo Reyes1, Robert Zakharyan2
1, Centro de Investigación Biomédicas del Noreste, Monterrey, México
2, Department of Molecular and Cellular Biology, University of Arizona, Tucson, Ari, Tucson, EE.UU., Investigador

Acceso a la fuente original
Biomedicine & Pharmacotherapy
http://www.elsevier.com/locate/biopha

El artículo se relaciona estrictamente con las especialidades de siicsalud
El artículo se conecta secundariamente con las especialidades
 


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