Amélia Ribeiro de Jesus *

Autora invitada por SIIC

Contribução para o entendimento dos mecanismos imunes que ocorrem nas fases mais precoces de evolução da esquistossomose.

O PERFIL DE CITOCINAS ASSOCIADO COM ESQUISTOSSOMOSE CRÔNICA HUMANA

Tanto o perfil de citocinas em células mononucleares do sangue periférico dos pacientes avaliados em graus de fibrose, bem como do perfil de citocinas daqueles que evoluíram com progressão de fibrose na segunda avaliação sugerem que as citocinas tipo 2 são mediadoras das etapas iniciais da fibrose hepática na esquistossomose.

*Amélia Ribeiro de Jesus
describe para SIIC los aspectos relevantes de su trabajo
ASSOCIATION OF TYPE 2 CYTOKINES WITH HEPATIC FIBROSIS IN HUMAN SCHISTOSOMA MANSONI INFECTION
Institución principal de la investigación
*Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Salvador, Brasil, Salvador, Brasil
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Referencias bibliográficas
1 Barreto ML, Loureiro S, Melo AS, Anjos CF. 1985. The effect of Schistosoma mansoni infection on child morbidity in the State of Bahia, Brazil. II-Analysis at the individual level. Rev Inst Med Trop Sao Paulo. 27: 167-71.2 De Jesus AM, Almeida RP, Bacellar O, Araujo MI, Demeure C, Bina JC, Dessein AJ, Carvalho EM. 1993. Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis. Eur J Immunol. 23: 152-8.3 Iarotski LS, Davis A. 1981. The schistosomiasis problem in the world: results of a WHO questionnaire survey. Bull World Health Organ. 59: 115-27.4 Bica I, Hamer DH, Stadecker MJ. 2000. Hepatic schistosomiasis. Infect Dis Clin North Am. 14: 583-604, viii.5 Neves DP. 1985. Parasitologia Humana, ed. Atheneu. Rio de Janeiro, Brasil.6 Pessoa SB, Martins AV. 1978. Parasitologia Medica, ed. G. Koogan. Rio de Janeiro, Brasil.7 Cheever AW, Williams ME, Wynn TA, Finkelman FD, Seder RA, Cox TM, Hieny S, Caspar P, Sher A. 1994. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol 153:753-9.8 Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA. 2001. Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 34:273-82.9 Metwali A, Elliott D, Mathew R, Blum A, Weinstock JV. 1993. IL-2 contributes to the IL-5 response in granulomas from mice infected with Schistosoma mansoni. J Immunol 150:536-42.

Otros artículos de Amélia Ribeiro de Jesus

Braga S, Porto A, Jesus AMR, Santos ALM, Jesus AR, Carvalho EM. Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection. Memórias do Instituto Oswaldo Cruz. Brasil, v.99, p.121-125, 2004.Braga S, Porto A, Santos ALM, Jesus AMR, Magalhaes E, Melo A, Dutra WO, Gollob KJ, Carvalho EM. Exacerbated inflamatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers. Microbiology Open Acess Research, v.3, p.7, 2004.Jesus AMR, Schrieffer A, Guimaraes LH, Carvalho LP, Almeida RP, Machado PR, Lessa H, Carvalho EM, Goes-Neto A, Schrieffer ALF. Multiclonal Leishmania braziliensis population structure and its clinical implication in a region of endemicity for American tegumentary leishmaniasis. Infection and Immunity. Estados Unidos: v.72, p.508-514, 2004.JESUS, Amélia Ribeiro; MAGALHÃES, Andréa Santos; SILVA, Angela; SANTANA, Luciana Barros; JESUS, Adriana Almeida de; ALMEIDA, Roque Pacheco ; RÊGO, Marco; BURATTINI, Marcelo; PEARCE, Edward; CARVALHO, Edgar. Clinical and Immunological Evaluation in 31 Patients with Acute Schistosomiasis mansoni. The Brazilian Journal Of Infectious Diseases, 2002.Jesus AR, Miranda DG, Miranda RG, Araujo I, Magalhaes AS, Bacellar O, Carvalho EM. Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area from Brazil, Caatinga do Moura. American Journal of Tropical Medicine and Hygiene, 2000.Jesus AR, Araújo I, Bacellar O, Magalhaes AS, Pearce E, Harn D, Strand M, Carvalho EM. Human immune responses to Schistosoma mansoni vaccine candidate antigens. Infection and Immunity, v.68, n.5, 2797-2803, 2000.Jesus AMR, Medeiros Junior M, Figueiredo JP, Almeida MC, Matos MA, Araujo MI, Cruz AA, Atta AM, Rego MAV, Taketomi EA, Carvalho EM. Schistosoma mansoni infection is associated with a reduced course of asthma. Journal of Allergy and Clinical Immunology. Estados Unidos, v.111, p.947-951, 2003.Mlb SA, Araújo MI, Jesus AMR, Almeida RP, Carvalho EM. Detection of specific IgE antibodies in parasitic diseases. Braz J Biol Med Res. , v.32, p.1101 - 1105, 1999.Araujo MI, Bacellar O, Jesus AMR, Carvalho EM. The absence of IFN-gamma production to S. mansoni antigens in patients with schistosomiasis. Brazilian Journal of Medical and Biological Research. v.27, p.1619-1625, 1994.Jesus AMR, Almeida RP, Bacellar O, Araújo MI, Demeure C, Bina JC, Dessein A, Carvalho EM. Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis. European Journal of Immunology. v.23, p.152-158, 1993.

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Acerca del trabajo completo

O PERFIL DE CITOCINAS ASSOCIADO COM ESQUISTOSSOMOSE CRÔNICA HUMANA

Título original en castellano
ASSOCIAÇÃO DE CITOCINAS TIPO 2 COM FIBROSE HEPATICA NA INFECÇÃO HUMANA POR SCHISTOSOMA MANSONI

Autor
Amélia Ribeiro de Jesus¹
1 Médica, Universidade Federal da Bahia, Professor Adjunto

Acceso a la fuente original
Infection and Immunity
http://iai.asm.org

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