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ALTERED SUBCELLULAR DISTRIBUTION OF DISC1, CAMP LEVELS, AND NEURONAL MIGRATION IN SCHIZOPHRENIA AND BIPOLAR DISORDER

DISC1 (disrupted-in-schizophrenia-1) is considered a genetic risk factor for neuropsychiatric disorders. In this study, analysis in human olfactory neuronal precursors of schizophrenia and bipolar disorder patients showed decreased DISC1 levels in the cytoplasm, cAMP accumulation and diminished cell migration. The results suggest that these disorders share common molecular pathways that could hinder the neurodevelopmental process.

The article was published by
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CNS Neuroscience & Therapeutics
Volume / Volumen: 21
Number / Número: 5
First and last pages / Páginas inicial-final: 446-453
Year / Año: 2015
Month / Mes: may


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Principal institution where the research took place
Institución principal de la investigación
CENTRO DE INVETIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO POLITECNICO NACIONAL, Mexico, Ciudad de México, D.F., Mexico


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Distribución Subcelular Anormal de DISC1, Niveles de AMPc y Migración Neuronal en la Esquizofrenia y el Trastorno Bipolar

El gen DISC1 (disrupted-in-schizophrenia-1) se considera un factor de riesgo de los trastornos neuropsiquiátricos. En este estudio, el análisis de los precursores neuronales olfatorios de pacientes con esquizofrenia y trastorno bipolar reveló niveles reducidos de DISC1 en el citoplasma, acumulación de AMPc y reducción de la migración celular. Los hallazgos sugieren que estas enfermedades comparten mecanismos moleculares que podrían comprometer el proceso del neurodesarrollo.
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Bibliographic references
Referencias bibliográficas

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Other articles written by the author Jesús Muñoz-Estrada
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Jesús Muñoz-Estrada was invited by SIIC on
Jesús Muñoz-Estrada fue invitado por SIIC el
2015, august 6
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7





The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

 
Neurology
/ Neurología
 
Mental Health
/ Salud Mental
 

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Anatomo-Pathology
Anatomía Patológica

Medical Education
Educación Médica

Pharmacology
Farmacología

Genetics
Genética Humana

Bioinformatics
Informática Biomédica

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Altered Subcellular Distribution of the 75-kDa DISC1 Isoform, cAMP Accumulation, and Decreased Neuronal Migration in Schizophrenia and Bipolar Disorder: Implications for Neurodevelopment


Author / Autor
Jesus Munoz-Estrada1, Gloria Benitez-King2, Isaura Meza3

3 Phd


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CNS Neuroscience & Therapeutics

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