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Casos clínicos

MASTOCITOSIS SISTEMICA ASOCIADA CON LA LEUCEMIA MIELOIDE AGUDA

El dasatinib parece asociarse con una adecuada respuesta hematológica en quienes coexiste una mastocitosis sistémica y una neoplasia hematológica. Los nuevos inhibidores de la tirosina quinasa representan una alternativa para optimizar el pronóstico de estos enfermos.
ustun9_n1810.jpg Autor
Celalettin Ustun
Columnista Experto de SIIC
Institución del autor
University of Minnesota, Mineápolis, EE.UU.

Artículos publicados por Celalettin Ustun
Coautores
Kapil Bhalla*   
Medical College of Georgia, Augusta, EE.UU.*

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Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página  http://siicsalud.com/dato/casiic.php/115087

Especialidades
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Primera edición en siicsalud
18 de enero, 2011

Bibliografía del caso clínico


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41. Yavuz A, Lipsky PE, Yavuz S, et al. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood 100:661-665, 2002
42. Akin C, Kirshenbaum AS, Semere T, et al. Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis. Exp Hematol 28:140-147, 2000.
43. Nagai S, Ichikawa M, Takahashi T, et al. The origin of neoplastic mast cells in systemic mastocytosis with AML1/ETO-positive acute myeloid leukemia Exp Hematol 35:1747-52, 2007.
44. Pullarkat V, Bedell V, Kim Y, et al. Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone. Leuk Res 31:261-5, 2007.
45. McClintock-Treep SA, Horny HP, Sotlar K, Foucar MK, Reichard KK. KIT(D816V+) systemic mastocytosis associated with KIT(D816V+) acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation. J Clin Pathol 62:1147-9, 2009.
 
Artículos publicados por el autor (selección)
Wang Y, Fiskus W, Chong DG, Buckley KM, Natarajan K, Rao R, Joshi A, Koul S, Chen J, Savoie A, Ustun C, Jillella A, Levine RL, Bhalla K. Co-treatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2-V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplasm cells Blood 114(114):33-33, 2009

Tanna Saloni, Ustun C. Immunosuppressive treatment in patient with pure red cell aplasia associated with chronic myelomonocytic leukemia; harm or benefit? International Journal of Hematology 90:597-600, 2009

Ustun C, Deremer D, Jillella A, Bhalla K. Investigational drugs targeting flt3 for leukemia Expert Opinion on Investigational Drugs 18:1445-1456, 2009

Fiskus W, Wang Y, Sreekumar A, Buckley K, Shi H, Jillella A, Ustun C, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells Blood 114:2733-2743, 2009

Subbannan K, Ustun C, Natarajan K, et al. Spleen related complications and implications of splenectomy in patients with hemoglobin SC disease International Journal of Hematology 83:258-260, 2009

Ustun C, Corless CL, Savage N, Fiskus W, Manaloor E, Heinrich MC, Lewis G, Ramalingam P, Kepten I, Jillella A, Bhalla K. Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT(D816V) Leukemia Research 33:735-741, 2009

Reid-Nicholson M, Nayak A, McDonald K, Crawford J, Jillella A, Ramalingham P. Plasmablastic lymphoma: CNS involvement, coexistence of other malignancies, possible viral etiology, and dismal outcome Annals of Hematology 88:351-358, 2009

Ustun C, Jillella AP, Salama ME. Dasatinib induces complete cytogenetic response and loss of F359C in an imatinib resistant chronic myelocytic leukemia patient American Journal of Hematology 84:386-387, 2009

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